| Autor: |
Kamdeu EN; Department of Organic Chemistry, Faculty of Sciences, University of Yaounde 1, Yaounde, Cameroon., Menye Nomo AN; Department of Organic Chemistry, Faculty of Sciences, University of Yaounde 1, Yaounde, Cameroon., Tchoukoua A; Department of Chemistry, Faculty of Science, University of Maroua, Maroua, Cameroon., Ngomo O; Department of Organic Chemistry, Faculty of Sciences, University of Yaounde 1, Yaounde, Cameroon., Djimeli Douanla P; Department of Organic Chemistry, Faculty of Sciences, University of Yaounde 1, Yaounde, Cameroon., Tchuendem Kenmogne MH; Department of Organic Chemistry, Faculty of Sciences, University of Yaounde 1, Yaounde, Cameroon., Shiono Y; Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata, Japan., Tabopda TK; Department of Organic Chemistry, Faculty of Sciences, University of Yaounde 1, Yaounde, Cameroon.; Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata, Japan. |
| Abstrakt: |
The phytochemical investigations of the tuber roots of Asparagus flagellaris led to the isolation of a new alkaloid, schweinfurthiamide ( 1 ) and eight known compounds. The structures of the isolated compounds were elucidated using spectroscopic techniques 1D and 2D NMR ( 1 H, 13 C, COSY, HMBC, HMQC, HSQC-TOCSY). The absolute configuration of 1 was unambiguously determined using DP4+ calculations. Compound 1 showed significant cytotoxicity against MCF-7 (breast cancer), NCI-H460 (lung cancer), and Hela (cervical cancer) cancer cell lines with IC 50 values of 1.18 ± 0.02 µM, 2.25 ± 0.19 µM, and 4.23 ± 0.26 µM, respectively and no toxicity against normal human fibroblast (BJ). |
