Methicillin-Resistant Staphylococcus aureus Bloodstream Infections in Hospitalized Patients in Peru.

Autor:	García C; Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.; Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru.; Departamento de Enfermedades Infecciosas, Tropicales y Dermatológicas, Hospital Cayetano Heredia, Lima, Peru., Hinostroza N; Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru., Gordillo V; Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru., Inchaustegui ML; Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru., Astocondor L; Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru., Chincha O; Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.; Departamento de Enfermedades Infecciosas, Tropicales y Dermatológicas, Hospital Cayetano Heredia, Lima, Peru., Alejos S; Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru., Olivera M; Servicio de Infectología y Medicina Tropical, Hospital María Auxiliadora, Lima, Peru., Bojórquez-Fernández D; Departamento de Patología ClÍnica y AnatomÍa Patológica, Hospital MarÍa Auxiliadora, Lima, Peru., Concha-Velasco F; Departamento de Medicina, Hospital Antonio Lorena, Cusco, Peru.; Escuela Profesional de Medicina Humana, Universidad Nacional San Antonio Abad del Cusco, Cusco, Peru., Vásquez N; Departamento de Apoyo al Diagnóstico, Hospital Antonio Lorena, Cusco, Peru., Castaneda-Sabogal A; Departamento de Medicina, Hospital Base Víctor Lazarte Echegaray de EsSalud, La Libertad, Peru.; Facultad de Medicina Humana, Universidad Privada Antenor Orrego, Trujillo, Peru., Sullón P; Departamento de Especilaidades Médicas, Hospital Hipólito Unanue, Lima, Peru., Fernández V; Departamento de Medicina, Hospital Belén de Trujillo, La Libertad, Peru., Villegas-Chiroque M; Departamento de Áreas Clínicas, Hospital Regional Lambayeque, Lambayeque, Peru., López E; Departamento de Medicina Hospital Regional de Loreto Felipe Santiago Arriola Iglesias, Loreto, Peru., Hueda-Zavaleta M; Faculty of Health Sciences, Universidad Privada de Tacna, Tacna, Peru.; Departamento de Medicina, Hospital III Daniel Alcides Carrión-EsSalud Tacna, Tacna, Peru., Vidaurre A; Departamento de Medicina, Hospital III EsSalud Chimbote, Ancash, Peru., Bocángel C; Departamento de Medicina Hospital Goyeneche de Arequipa, Arequipa, Peru., Barco E; Departamento de Patología Clínica, Hospital Regional II-2 José Alfredo Mendoza Olavarría, Tumbes, Peru., Paricahua E; Departamento de Medicina, Hospital Santa Rosa de Puerto Maldonado, Madre de Dios, Peru., Zervos M; Infectious Disease Division, Henry Ford Health System, Detroit, Michigan., Jacobs J; Institute of Tropical Medicine, Antwerp, Belgium.; Department of Microbiology, Immunology and Transplantation, KU Leuven, Belgium., Krapp F; Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.; Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru.; Department of Microbiology, Immunology and Transplantation, KU Leuven, Belgium.
Jazyk:	angličtina
Zdroj:	The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2023 Sep 18; Vol. 109 (5), pp. 1118-1121. Date of Electronic Publication: 2023 Sep 18 (Print Publication: 2023).
DOI:	10.4269/ajtmh.23-0054
Abstrakt:	There is a knowledge gap in the epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) causing bloodstream infections (BSIs) in Peru. Through a surveillance study in 13 hospitals of 10 Peruvian regions (2017-2019), we assessed the proportion of MRSA among S. aureus BSIs as well as the molecular typing of the isolates. A total of 166 S. aureus isolates were collected, and 36.1% of them were MRSA. Of note, MRSA isolates with phenotypic and genetic characteristics of the hospital-associated Chilean-Cordobes clone (multidrug-resistant SCCmec I, non-Panton-Valentine leukocidin [PVL] producers) were most commonly found (70%), five isolates with genetic characteristics of community-associated MRSA (CA-MRSA)-SCCmec IV, PVL-producer-(8.3%) were seen in three separate regions. These results demonstrate that hospital-associated MRSA is the most frequent MRSA found in patients with BSIs in Peru. They also show the emergence of S. aureus with genetic characteristics of CA-MRSA. Further studies are needed to evaluate the extension of CA-MRSA dissemination in Peru.
Databáze:	MEDLINE
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