Omega-3 fatty acids prevent nicotine withdrawal-induced impairment of learning and memory via affecting oxidative status, inflammatory response, cholinergic activity, BDNF and amyloid-B in rat hippocampal tissues.

Autor: Ahmadi-Soleimani SM; Departments of Physiology, School of Medicine, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran; Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran., Amiry GY; Student Research Committee, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran., Khordad E; Department of Anatomical Sciences, School of Medicine, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran., Masoudi M; Vice Chancellery of Education and Research, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran., Beheshti F; Departments of Physiology, School of Medicine, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran; Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran. Electronic address: beheshtif1@thums.ac.ir.
Jazyk: angličtina
Zdroj: Life sciences [Life Sci] 2023 Nov 01; Vol. 332, pp. 122100. Date of Electronic Publication: 2023 Sep 17.
DOI: 10.1016/j.lfs.2023.122100
Abstrakt: In the present study, the main objective was to reveal whether treatment by Omega-3 fatty acids could prevent the adverse effects of adolescent nicotine withdrawal on spatial and avoidance memory in male rats. For this purpose, Morris water maze and passive avoidance tests were performed on male Wistar rats and the hippocampal levels of oxidative stress markers, inflammatory indices, brain-derived neurotrophic factor, nitrite, amyloid-B and acetylcholinesterase (AChE) were measured. Moreover, density of dark neurons were assessed in CA 1 and CA 3 regions. Results showed that adolescent nicotine exposure followed by a period of drug cessation exacerbates the behavioral indices of learning and memory through affecting a variety of biochemical markers within the hippocampal tissues. These changes lead to elevation of oxidative and inflammatory markers, reduction of neurotrophic capacity and increased AChE activity in hippocampal tissues. In addition, it was observed that co-administration of nicotine with Omega-3 fatty acids significantly prevents nicotine withdrawal-induced adverse effects through restoration of the mentioned biochemical disturbances. Therefore, we suggest administration of Omega-3 fatty acids as a safe, inexpensive and effective therapeutic strategy for prevention of memory dysfunctions associated with nicotine abstinence during adolescence.
Competing Interests: Declaration of competing interest The authors declare no conflict of interest related to this study.
(Copyright © 2023. Published by Elsevier Inc.)
Databáze: MEDLINE
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