Neural circuit mechanisms for transforming learned olfactory valences into wind-oriented movement.

Autor:	Aso Y; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Yamada D; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, United States., Bushey D; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Hibbard KL; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Sammons M; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Otsuna H; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Shuai Y; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Hige T; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, United States.; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, United States.; Integrative Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2023 Sep 18; Vol. 12. Date of Electronic Publication: 2023 Sep 18.
DOI:	10.7554/eLife.85756
Abstrakt:	How memories are used by the brain to guide future action is poorly understood. In olfactory associative learning in Drosophila , multiple compartments of the mushroom body act in parallel to assign a valence to a stimulus. Here, we show that appetitive memories stored in different compartments induce different levels of upwind locomotion. Using a photoactivation screen of a new collection of split-GAL4 drivers and EM connectomics, we identified a cluster of neurons postsynaptic to the mushroom body output neurons (MBONs) that can trigger robust upwind steering. These UpWind Neurons (UpWiNs) integrate inhibitory and excitatory synaptic inputs from MBONs of appetitive and aversive memory compartments, respectively. After formation of appetitive memory, UpWiNs acquire enhanced response to reward-predicting odors as the response of the inhibitory presynaptic MBON undergoes depression. Blocking UpWiNs impaired appetitive memory and reduced upwind locomotion during retrieval. Photoactivation of UpWiNs also increased the chance of returning to a location where activation was terminated, suggesting an additional role in olfactory navigation. Thus, our results provide insight into how learned abstract valences are gradually transformed into concrete memory-driven actions through divergent and convergent networks, a neuronal architecture that is commonly found in the vertebrate and invertebrate brains. Competing Interests: YA, DY, DB, KH, MS, HO, YS, TH No competing interests declared (© 2023, Aso et al.)
Databáze:	MEDLINE
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