Radiation exposure determination in a secure, cloud-based online environment.
| Autor: | Shirley BC; CytoGnomix Inc., 60 N. Centre Rd., London Ontario N5X 3X5, Canada., Mucaki EJ; Dept. Biochemistry, University of Western Ontario, London Ontario N6A 3K7, Canada., Knoll JHM; CytoGnomix Inc., 60 N. Centre Rd., London Ontario N5X 3X5, Canada.; Dept. Pathology and Laboratory Medicine, University of Western Ontario, London Ontario N6A 3K7, Canada., Rogan PK; CytoGnomix Inc., 60 N. Centre Rd., London Ontario N5X 3X5, Canada.; Dept. Biochemistry, University of Western Ontario, London Ontario N6A 3K7, Canada. |
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| Jazyk: | angličtina |
| Zdroj: | Radiation protection dosimetry [Radiat Prot Dosimetry] 2023 Sep 18; Vol. 199 (14), pp. 1465-1471. |
| DOI: | 10.1093/rpd/ncac266 |
| Abstrakt: | Rapid sample processing and interpretation of estimated exposures will be critical for triaging exposed individuals after a major radiation incident. The dicentric chromosome (DC) assay assesses absorbed radiation using metaphase cells from blood. The Automated Dicentric Chromosome Identifier and Dose Estimator System (ADCI) identifies DCs and determines radiation doses. This study aimed to broaden accessibility and speed of this system, while protecting data and software integrity. ADCI Online is a secure web-streaming platform accessible worldwide from local servers. Cloud-based systems containing data and software are separated until they are linked for radiation exposure estimation. Dose estimates are identical to ADCI on dedicated computer hardware. Image processing and selection, calibration curve generation, and dose estimation of 9 test samples completed in < 2 days. ADCI Online has the capacity to alleviate analytic bottlenecks in intermediate-to-large radiation incidents. Multiple cloned software instances configured on different cloud environments accelerated dose estimation to within clinically relevant time frames. (© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.) |
| Databáze: | MEDLINE |
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