A preliminary report on retrospective dose assessment by FISH translocation assay in FDNPP Nuclear Emergency Worker Study (NEWS).

Autor:	Abe Y; Department of Radiation Biology and Protection, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523 Japan., Takashima Y; Department of Radiation Measurement and Dose Assessment, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 Japan., Akiyama M; Department of Radiation Measurement and Dose Assessment, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 Japan., Tsuyama N; Department of Radiation Life Sciences, Fukushima Medical University, 1 Hikariga-oka, Fukushima 960-1295 Japan., Takebayashi K; Department of Risk Analysis and Biodosimetry, Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki 036-8564, Japan., Nakayama R; Department of Risk Analysis and Biodosimetry, Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki 036-8564, Japan., Goh VST; Department of Radiobiology, Singapore Nuclear Research and Safety Initiative, National University of Singapore, 1 CREATE Way, #04-01 CREATE Tower, 138602 Singapore., Sugai-Takahashi M; Department of Radiation Life Sciences, Fukushima Medical University, 1 Hikariga-oka, Fukushima 960-1295 Japan., Alkebsi L; Department of Radiation Measurement and Dose Assessment, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 Japan., Ishii K; Department of Radiation Measurement and Dose Assessment, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 Japan., Kudo K; Department of Radiation Life Sciences, Fukushima Medical University, 1 Hikariga-oka, Fukushima 960-1295 Japan., Sakai A; Department of Radiation Life Sciences, Fukushima Medical University, 1 Hikariga-oka, Fukushima 960-1295 Japan., Kurihara O; Department of Radiation Measurement and Dose Assessment, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 Japan., Miura T; Department of Risk Analysis and Biodosimetry, Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki 036-8564, Japan., Suto Y; Department of Radiation Measurement and Dose Assessment, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 Japan., Akashi M; Tachikawa Faculty of Nursing, Tokyo Healthcare University, 3256 Midorimachi, Tachikawa 109-8590, Japan.
Jazyk:	angličtina
Zdroj:	Radiation protection dosimetry [Radiat Prot Dosimetry] 2023 Sep 18; Vol. 199 (14), pp. 1565-1571.
DOI:	10.1093/rpd/ncad053
Abstrakt:	In Japan, a national project of longitudinal health care and epidemiological research (NEWS) was developed in 2014 to analyse the effects of radiation on human health for workers who responded to the Fukushima Dai-ichi nuclear emergency in 2011. In 2018, peripheral blood for chromosome translocation analysis was collected from 62 workers. Retrospective dose assessment was performed with fluorescence in situ hybridisation translocation (FISH-Tr) assay. The range of estimated doses by FISH-Tr assay was 0-635 mGy, in which 22 workers had estimated doses of more than 189 mGy. Biological dose estimates were five times higher in workers with physically measured total exposure recordings above 70 mGy. It is likely that smoking and medical exposure caused the discrepancy between estimated biological and physical total exposure doses. Thus, there is a possibility that retrospective biodosimetry assessment might over-estimate occupational exposures to workers exposed to chronic radiation during nuclear emergency work. (© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu