High-fat ketogenic diets and ketone monoester supplements differentially affect substrate metabolism during aerobic exercise.

Autor:	Margolis LM; Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States., Pasiakos SM; Office of Dietary Supplements, U.S. Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland, United States., Howard EE; Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States.
Jazyk:	angličtina
Zdroj:	American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2023 Oct 01; Vol. 325 (4), pp. C1144-C1153. Date of Electronic Publication: 2023 Sep 18.
DOI:	10.1152/ajpcell.00359.2023
Abstrakt:	Chronically adhering to high-fat ketogenic diets or consuming ketone monoester supplements elicits ketosis. Resulting changes in substrate metabolism appear to be drastically different between ketogenic diets and ketone supplements. Consuming a ketogenic diet increases fatty acid oxidation with concomitant decreases in endogenous carbohydrate oxidation. Increased fat oxidation eventually results in an accumulation of circulating ketone bodies, which are metabolites of fatty acids that serve as an alternative source of fuel. Conversely, consuming ketone monoester supplements rapidly increases circulating ketone body concentrations that typically exceed those achieved by adhering to ketogenic diets. Rapid increases in ketone body concentrations with ketone monoester supplementation elicit a negative feedback inhibition that reduces fatty acid mobilization during aerobic exercise. Supplement-derived ketosis appears to have minimal impact on sparing of muscle glycogen or minimizing of carbohydrate oxidation during aerobic exercise. This review will discuss the substrate metabolic and associated aerobic performance responses to ketogenic diets and ketone supplements.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu