Utilization of an Automated Latex Agglutination Turbidity Assay for Assessing Gastric Mucosal Alteration during Helicobacter pylori Infection.

Autor: Khangai A; Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Japan.; The Gastroenterology Center, The First Central Hospital of Mongolia, Ulaanbaatar, Mongolia., Akada J; Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Japan., Saruuljavkhlan B; Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Japan., Gantuya B; Department of Gastroenterology, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.; Endoscopy Unit, Mongolia-Japan Teaching Hospital, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia., Azzaya D; Department of Gastroenterology, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.; Endoscopy Unit, Mongolia-Japan Teaching Hospital, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia., Oyuntsetseg K; Department of Gastroenterology, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.; Endoscopy Unit, Mongolia-Japan Teaching Hospital, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia., Davaadorj D; Department of Gastroenterology, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.; Endoscopy Unit, Mongolia-Japan Teaching Hospital, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia., Uchida T; Department of Advanced Medical Sciences, Oita University Faculty of Medicine, Oita, Japan., Matsumoto T; Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Japan., Yamaoka Y; Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Japan.; Research Center for Global and Local Infectious Diseases (RCGLID), Oita University, Oita, Japan.; Department of Medicine, Gastroenterology and Hepatology Section, Baylor College of Medicine, Houston, TX, USA.
Jazyk: angličtina
Zdroj: Gut and liver [Gut Liver] 2024 Jan 15; Vol. 18 (1), pp. 60-69. Date of Electronic Publication: 2023 Sep 18.
DOI: 10.5009/gnl220464
Abstrakt: Background/aims: : A latex agglutination turbidity (LA) assay to test for serum antibodies has been approved in Japan and Korea for mass screening of Helicobacter pylori infection. In this study, we evaluated the LA assay for diagnosing H. pylori infection and predicting gastric mucosal changes in a Mongolian population.
Methods: : In total, 484 individuals were classified into H. pylori -positive (n=356) and H. pylori -negative (n=128) groups, as determined by histology and H. pylori culture.
Results: : The best cutoff, sensitivity, and specificity values for the LA assay were 18.35 U/mL, 74.2%, and 65.6%, respectively. The LA values in the atrophic gastritis group were statistically higher than those in the other groups (healthy, chronic gastritis, intestinal metaplasia, and gastric cancer, p<0.0001). The cutoff value to distinguish the atrophic gastritis group from the other four groups was 32.0 U/mL, and its area under the curve was 0.673, which was the highest among the E-plate, pepsinogen (PG) I, PG II, and PG I/II ratio tests in our data. The odds ratios for atrophic gastritis determined by the LA assay and PG I test in multiple logistic regression were 2.5 and 1.9, respectively, which were significantly higher than for the other tests.
Conclusions: : The LA assay can determine the risk of atrophic gastritis, which in turn is a considerable risk factor for gastric cancer. We propose using this assay in combination with the PG I/II ratio to avoid missing gastric cancer patients who have a low LA value (less than 32.0 U/mL).
Databáze: MEDLINE
Externí odkaz: