Impact of local drug delivery and natural agents as new target strategies against periodontitis: new challenges for personalized therapeutic approach.

Autor:	Viglianisi G; Department of General Surgery and Surgical-Medical Specialities, School of Dentistry, University of Catania, Catania, Italy., Santonocito S; Department of General Surgery and Surgical-Medical Specialities, School of Dentistry, University of Catania, Catania, Italy., Lupi SM; Department of Clinical Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy., Amato M; Department of General Surgery and Surgical-Medical Specialities, School of Dentistry, University of Catania, Catania, Italy., Spagnuolo G; Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples 'Federico II', Naples, Italy., Pesce P; Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy., Isola G; Department of General Surgery and Surgical-Medical Specialities, School of Dentistry, University of Catania, Via Santa Sofia 78, Catania 95123, Italy.
Jazyk:	angličtina
Zdroj:	Therapeutic advances in chronic disease [Ther Adv Chronic Dis] 2023 Sep 13; Vol. 14, pp. 20406223231191043. Date of Electronic Publication: 2023 Sep 13 (Print Publication: 2023).
DOI:	10.1177/20406223231191043
Abstrakt:	Periodontitis is a persistent inflammation of the soft tissue around the teeth that affects 60% of the population in the globe. The self-maintenance of the inflammatory process can cause periodontal damage from the alveolar bone resorption to tooth loss in order to contrast the effects of periodontitis, the main therapy used is scaling and root planing (SRP). At the same time, studying the physiopathology of periodontitis has shown the possibility of using a local drug delivery system as an adjunctive therapy. Using local drug delivery devices in conjunction with SRP therapy for periodontitis is a potential tool since it increases drug efficacy and minimizes negative effects by managing drug release. This review emphasized how the use of local drug delivery agents and natural agents could be promising adjuvants for the treatment of periodontitis patients affected or not by cardiovascular disease, diabetes, and other system problems. Moreover, the review evidences the current issues and new ideas that can inspire potential later study for both basic research and clinical practice for a tailored approach. Competing Interests: The authors declare that there is no conflict of interest. (© The Author(s), 2023.)
Databáze:	MEDLINE
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