The canonical HPA axis facilitates and maintains light adaptive behavior.

Autor:	Lee H; Mayo Clinic., Shams S; Mayo Clinic., Dang Thi VH; Mayo Clinic., Boyum G; Mayo Clinic., Modhurima R; Mayo Clinic., Hall E; Mayo Clinic., Green I; Mayo Clinic., Cervantes E; Mayo Clinic., Miguez F; Iowa State University., Clark K; Mayo Clinic.
Jazyk:	angličtina
Zdroj:	Research square [Res Sq] 2023 Sep 06. Date of Electronic Publication: 2023 Sep 06.
DOI:	10.21203/rs.3.rs-3240080/v1
Abstrakt:	The vertebrate stress response (SR) is mediated by the hypothalamic-pituitary-adrenal (HPA) axis and contributes to generating context appropriate physiological and behavioral changes. Although the HPA axis plays vital roles both in stressful and basal conditions, research has focused on the response under stress. To understand broader roles of the HPA axis in a changing environment, we characterized an adaptive behavior of larval zebrafish during ambient illumination changes. The glucocorticoid receptor ( nr3c1 ) was necessary to maintain basal locomotor activity in light and darkness. The HPA axis was required to adapt to light more efficiently but became dispensable when longer illumination was provided. Light adaptation was more efficient in dimmer light and did not require the mineralocorticoid receptor ( nr3c2 ). Our findings show that the HPA axis contributes to the SR at various stages, facilitating the phasic response and maintaining an adapted basal state, and that certain adaptations occur without HPA axis activity. Competing Interests: All authors declare no conflict of interest regarding this manuscript.
Databáze:	MEDLINE
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