Focusing on the Native Matrix Proteins in Calcific Aortic Valve Stenosis.
| Autor: | Anousakis-Vlachochristou N; National and Kapodistrian University of Athens, Medical School, First Department of Cardiology, Athens, Greece., Athanasiadou D; Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada., Carneiro KMM; Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada., Toutouzas K; National and Kapodistrian University of Athens, Medical School, First Department of Cardiology, Athens, Greece. |
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| Jazyk: | angličtina |
| Zdroj: | JACC. Basic to translational science [JACC Basic Transl Sci] 2023 Mar 29; Vol. 8 (8), pp. 1028-1039. Date of Electronic Publication: 2023 Mar 29 (Print Publication: 2023). |
| DOI: | 10.1016/j.jacbts.2023.01.009 |
| Abstrakt: | Calcific aortic valve stenosis (CAVS) is a widespread valvular heart disease affecting people in aging societies, primarily characterized by fibrosis, inflammation, and progressive calcification, leading to valve orifice stenosis. Understanding the factors associated with CAVS onset and progression is crucial to develop effective future pharmaceutical therapies. In CAVS, native extracellular matrix proteins modifications, play a significant role in calcification in vitro and in vivo. This work aimed to review the evidence on the alterations of structural native extracellular matrix proteins involved in calcification development during CAVS and highlight its link to deregulated biomechanical function. Competing Interests: Drs Anousakis-Vlachochristou, Athanasiadou, and Toutouzas acknowledge the European Union (E.U.), and Greek funds through the Operational Program “Human Resources Development, Education and Lifelong Learning” (NSRF 2014-2020), under the call “Supporting Researchers with an Emphasis on Young Researchers – Cycle B” (MIS: 5047949), Athens, Greece, for funding. Dr Carneiro has reported that she has no relationships relevant to the contents of this paper to disclose. (© 2023 The Authors.) |
| Databáze: | MEDLINE |
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