Serum Amyloid A as a Potential Biomarker for Disease Activity in Chronic Spontaneous Urticaria.

Autor: Carvallo A; Department of Allergy and Clinical Immunology, Clínica Universidad de Navarra, Pamplona, Spain., Veleiro B; Allergy Department, Complexo Hospitalario Universitario A Coruña, A Coruña, Spain., Sabaté-Brescó M; Department of Allergy and Clinical Immunology, Clínica Universidad de Navarra, Pamplona, Spain; Immune, Infectious and Inflammatory Diseases Research, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain; RICORS Red De Enfermedades Inflamatorias (REI), Madrid, Spain. Electronic address: msabate@unav.es., Baeza ML; Allergy Service, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Biomedical Research Network on Rare Diseases (CIBERER)-U761, Gregorio Marañón Health Research Institute, Madrid, Spain., Guilarte M; Allergy Section, Internal Medicine Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain., Herrera-Lasso V; Allergy Section, Hospital Universitari Joan XXIII de Tarragona, Tarragona, Spain., Rodríguez-Garijo N; Department of Dermatology, Clínica Universidad de Navarra, Pamplona, Spain., Diaz Donado C; Allergy Section, Hospital Universitario Central de Asturias, Oviedo, Spain., Labrador-Horrillo M; Allergy Section, Internal Medicine Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain., Ferrer M; Department of Allergy and Clinical Immunology, Clínica Universidad de Navarra, Pamplona, Spain; Immune, Infectious and Inflammatory Diseases Research, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain; RICORS Red De Enfermedades Inflamatorias (REI), Madrid, Spain.
Jazyk: angličtina
Zdroj: The journal of allergy and clinical immunology. In practice [J Allergy Clin Immunol Pract] 2024 Jan; Vol. 12 (1), pp. 195-200. Date of Electronic Publication: 2023 Sep 15.
DOI: 10.1016/j.jaip.2023.09.004
Abstrakt: Background: Chronic spontaneous urticaria (CSU) is an inflammatory skin disease with a complex physiopathology. Serum amyloid A (SAA), an acute-phase reactant, has been proposed as a potential biomarker in urticaria but has yet to be studied in a population with CSU or correlated with disease activity as indicated by the Urticaria Activity Score summed over 7 days (UAS7).
Objective: We sought to determine SAA-1 levels in patients with CSU and correlate them with its activity and control, as well as with clinical features of CSU and other potential blood biomarkers.
Methods: We conducted a retrospective multicenter study of 67 patients with CSU, from whom we obtained demographic and clinical data, UAS7 as an indicator of CSU activity, and blood and serum markers.
Results: SAA-1 levels positively correlated with UAS7 (r s  = 0.47, P < .001). SAA-1 levels were higher in patients with noncontrolled (UAS7 > 6) CSU than in those with controlled (UAS ≤ 6) CSU (P < .001) and were also higher in patients with concomitant angioedema (P = .003) or delayed pressure urticaria (P = .003).
Conclusion: We propose SAA-1 as a potential biomarker for activity in CSU. Further studies are required to evaluate its potential role as a biomarker for other CSU outcomes, such as response to treatment.
(Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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