11-item modified frailty index and outcomes after radical cystectomy.

Autor: Savin Z; Department of Urology, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, , Tel-Aviv, Israel. Electronic address: zivsavin23@gmail.com., Yossepowitch O; Department of Urology, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, , Tel-Aviv, Israel., Lazarovich A; Department of Urology, Chaim Sheba Medical Center, Ramat-Gan, Israel., Rosenzwieg B; Department of Urology, Chaim Sheba Medical Center, Ramat-Gan, Israel; Israeli Urologic Oncology Collaboration (IUOC)., Shashar R; Department of Urology, Rambam Health Center, Haifa, Israel., Hoffman A; Department of Urology, Rambam Health Center, Haifa, Israel; Israeli Urologic Oncology Collaboration (IUOC)., Gal J; Department of Urology, Shamir Medical Center, Be'er Ya'akov, Israel., Haifler M; Department of Urology, Chaim Sheba Medical Center, Ramat-Gan, Israel; Israeli Urologic Oncology Collaboration (IUOC)., Pilosov I; Department of Urology, Carmel Medical Center, Haifa, Israel., Frifeld Y; Department of Urology, Carmel Medical Center, Haifa, Israel; Israeli Urologic Oncology Collaboration (IUOC)., Shpitzer SA; Department of Urology, Rabin Medical Center, Petach-Tikva, Israel., Golan S; Department of Urology, Rabin Medical Center, Petach-Tikva, Israel; Israeli Urologic Oncology Collaboration (IUOC)., Mano R; Department of Urology, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, , Tel-Aviv, Israel; Israeli Urologic Oncology Collaboration (IUOC).
Jazyk: angličtina
Zdroj: Journal of geriatric oncology [J Geriatr Oncol] 2023 Nov; Vol. 14 (8), pp. 101627. Date of Electronic Publication: 2023 Sep 14.
DOI: 10.1016/j.jgo.2023.101627
Abstrakt: Introduction: To investigate the association between modified frailty index (mFI) scores and radical cystectomy outcomes.
Materials and Methods: We conducted a multicenter retrospective analysis of 292 patients who underwent radical cystectomy between 2015 and 2019. The patients were stratified according to mFI scores (mFI 0-1 vs. mFI ≥2). Baseline characteristics were compared between groups. The primary endpoints were cancer-specific survival (CSS) and overall survival (OS), and the secondary endpoint was the 30-day postoperative complication rate.
Results: One group included 164 patients with mFI 0-1 and the other included 128 patients with mFI ≥2. The cohort's median age was 69 years, and median follow-up for survivors was 33 months. Thirty-day major postoperative complication rate was 19%. Ninety patients (31%) died during the study period, 70 of them (24%) from bladder cancer. Older age, male sex, lower kidney function, and diversion to an ileal conduit were significantly more common in the mFI ≥2 group. The postoperative complication rates were comparable between groups, but the CSS and OS were significantly lower in the frailer group (p = 0.007 and p = 0.03, respectively). An mFI score ≥ 2 emerged as an independent risk factor for cancer-specific death (hazard ratio [HR] = 1.7, p = 0.03) and overall-mortality (HR = 1.8, p = 0.008).
Discussion: High mFI scores are associated with shorter CSS and OS after radical cystectomy. Healthcare providers should be encouraged to calculate frailty preoperatively for judicious patient selection in light of the predicted outcomes.
Competing Interests: Declaration of Competing Interest Roy Mano is a paid consultant for N1X10.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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