Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury.

Autor:	Veniaminova NA; Department of Dermatology, Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA., Jia YY; Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA., Hartigan AM; Department of Dermatology, Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA., Huyge TJ; Department of Dermatology, Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA., Tsai SY; Department of Dermatology, Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA., Grachtchouk M; Department of Dermatology, Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA., Nakagawa S; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Dermatology, Department of Cutaneous Immunology and Microbiology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan., Dlugosz AA; Department of Dermatology, Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA., Atwood SX; Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA. Electronic address: satwood@uci.edu., Wong SY; Department of Dermatology, Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: sunnyw@umich.edu.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2023 Sep 26; Vol. 42 (9), pp. 113121. Date of Electronic Publication: 2023 Sep 19.
DOI:	10.1016/j.celrep.2023.113121
Abstrakt:	Sebaceous glands (SGs) release oils that protect our skin, but how these glands respond to injury has not been previously examined. Here, we report that SGs are largely self-renewed by dedicated stem cell pools during homeostasis. Using targeted single-cell RNA sequencing, we uncovered both direct and indirect paths by which resident SG progenitors ordinarily differentiate into sebocytes, including transit through a Krt5+PPARγ+ transitional basal cell state. Upon skin injury, however, SG progenitors depart their niche, reepithelialize the wound, and are replaced by hair-follicle-derived stem cells. Furthermore, following targeted genetic ablation of >99% of SGs from dorsal skin, these glands unexpectedly regenerate within weeks. This regenerative process is mediated by alternative stem cells originating from the hair follicle bulge, is dependent upon FGFR2 signaling, and can be accelerated by inducing hair growth. Altogether, our studies demonstrate that stem cell plasticity promotes SG durability following injury. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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