Antioxidant, Diabetic and Inflammatory Activities of Alpinia calcarata Roscoe Extract.

Autor: Devi NM; Department of Chemistry, National Institute of Technology-Manipur, Langol, 795004, Manipur, India.; Plant Bioresource Division, Institute of Bioresources and Sustainable Development, Imphal, 795001, Manipur, India., Nagarajan S; Department of Chemistry, National Institute of Technology-Manipur, Langol, 795004, Manipur, India., Singh CB; Plant Bioresource Division, Institute of Bioresources and Sustainable Development, Imphal, 795001, Manipur, India., Khan MMA; Applied Science and Humanities Section, University Polytechnic, Faculty of Engineering and Technology, Aligarh Muslim University, Aligarh, 202002, India., Khan A; Center for Biotechnology, Maharshi Dayanand University, Rohtak, 124001, India., Khan N; Department of Biotechnology, UIET, Maharshi Dayanand University, Rohtak, 124001, Haryana, India., Mahmoud MH; Department of Biochemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia-, 11451., Fouad H; Biomedical Engineering Dept. Faculty of Engineering, Helwan University, Helwan, Egypt-, 11795., Ansari A; Department of Obstetrics and Gyenocology and Ewha Medical Research Institute, College of Medicine, EwhaWomens University, Seoul, 07984, Republic of Korea.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Jun; Vol. 21 (6), pp. e202300970. Date of Electronic Publication: 2023 Oct 09.
DOI: 10.1002/cbdv.202300970
Abstrakt: Background: Alpinia calcarata (AC) Roscoe of Zingiberaceae popularly known as lesser galangal has a widespread occurrence in China, India, Sri-Lanka, Bangladesh, Malaysia, Indonesia and Thailand. Essential oil (Eoil) was obtained from leaves/rhizomes of AC via hydro-distillation process.
Methods: To identify chemical ingredients in oil from leaves/rhizomes of AC through GC/MS technique for volatile components and their anti-oxidant, inflammatory/diabetic activities.
Results: The 38 and 65 components were found to make up 99.9 and 99.6 %, respectively in total of Eoil composition of AC leaves/rhizomes. Key chemical constituents were eucalyptol (28.7 % in leaves; 25.4 % in rhizomes), camphor (12.8 % in leaves; 4.2 % in rhizomes), and carotol (9.8 % in leaves; 5.6 % in rhizomes) found in oil of AC leaves/rhizomes. Colorimetric assay showed anti-oxidant activities in leaves and rhizomes are IC 50 =71.01±0.71 μg/mL and IC 50 =73.83±0.49 μg/mL, respectively in the Eoils. Eoils had high anti-oxidant capabilities in IC 50 -values of AC-L-Eoil=43.09±0.82&AC-Rh-Eoil=68.11±0.87 in reducing power in μg/mL was found. Albumin test of rhizome oil had IC 50 -values of 15.19±0.25 μg/mL. Concentrations range of 7.81 μg/mL and 250 μg/mL in the Eoils of AC leaves and rhizome, respectively by α-glucosidase inhibition assay.
Conclusion: Our findings demonstrated that leaf oil was slightly more promising results than rhizome oil of AC extract, which was ultimately showed medicinal potential of secondary metabolites with anti-oxidant, diabetic/inflammatory activities. Further, Eoils of AC have a wide range of pharmacological potential and promising anti-diabetic effects.
(© 2023 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
Externí odkaz: