Successful treatment of multidrug-resistant Pseudomonas aeruginosa keratitis with meropenem eye drops - a case report.

Autor: Elhardt C; Department of Ophthalmology, University Hospital Ulm, Prittwitzstrasse 43, 89075, Ulm, Germany. Carolin.Elhardt@uniklinik-ulm.de., Wolf A; Department of Ophthalmology, University Hospital Ulm, Prittwitzstrasse 43, 89075, Ulm, Germany., Wertheimer CM; Department of Ophthalmology, University Hospital Ulm, Prittwitzstrasse 43, 89075, Ulm, Germany.
Jazyk: angličtina
Zdroj: Journal of ophthalmic inflammation and infection [J Ophthalmic Inflamm Infect] 2023 Sep 16; Vol. 13 (1), pp. 40. Date of Electronic Publication: 2023 Sep 16.
DOI: 10.1186/s12348-023-00363-0
Abstrakt: Background: This case report describes the course and therapeutic management of a fast-spreading bacterial keratitis caused by multidrug-resistant (MDR) Pseudomonas aeruginosa (P. aeruginosa).
Case Presentation: A 27-year-old male contact lens wearer presented with a multi-resistant, fast spreading P. aeruginosa keratitis. After initial resistance to various antibiotic therapies, testing revealed a MDR P. aeruginosa. The keratitis was treated successfully with specially prepared 50 mg/ml off-label meropenem eye drops for 18 days as well as systemic meropenem for seven days with rapid improvement of the corneal infiltrate.
Conclusion: This case report demonstrates the combination of topical and systemic meropenem as a useful treatment option for corneal ulcers caused by MDR P. aeruginosa.
(© 2023. Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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