Targeted cancer treatment using folate-conjugated sponge-like ZIF-8 nanoparticles: a review.

Autor: Oryani MA; Department of Pathology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Nosrati S; Department of Clinical Biochemistry, Faculty of Medicine, Azad Shahroud University, Shahroud, Iran., Javid H; Department of Medical Laboratory Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran. Javidh@varastegan.ac.ir.; Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Javidh@varastegan.ac.ir.; Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Javidh@varastegan.ac.ir., Mehri A; Endoscopic and Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran., Hashemzadeh A; Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Karimi-Shahri M; Department of Pathology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Labratorylabratory@yahoo.com.; Department of Pathology, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran. Labratorylabratory@yahoo.com.
Jazyk: angličtina
Zdroj: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 Mar; Vol. 397 (3), pp. 1377-1404. Date of Electronic Publication: 2023 Sep 16.
DOI: 10.1007/s00210-023-02707-y
Abstrakt: ZIF-8 (zeolitic imidazolate framework-8) is a potential drug delivery system because of its unique properties, which include a large surface area, a large pore capacity, a large loading capacity, and outstanding stability under physiological conditions. ZIF-8 nanoparticles may be readily functionalized with targeting ligands for the identification and absorption of particular cancer cells, enhancing the efficacy of chemotherapeutic medicines and reducing adverse effects. ZIF-8 is also pH-responsive, allowing medication release in the acidic milieu of cancer cells. Because of its tunable structure, it can be easily functionalized to design cancer-specific targeted medicines. The delivery of ZIF-8 to cancer cells can be facilitated by folic acid-conjugation. Hence, it can bind to overexpressed folate receptors on the surface of cancer cells, which holds the promise of reducing unwanted deliveries. As a result of its importance in cancer treatment, the folate-conjugated ZIF-8 was the major focus of this review.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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