Disposition kinetics of meloxicam in green sea turtles (Chelonia mydas) after intravenous and intramuscular administrations.

Autor: Poapolathep A; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand., Jongkolpath O; Eastern Marine and Coastal Resources Research and Development Center, Rayong, Thailand., Giorgi M; Department of Veterinary Sciences, University of Pisa, San Piero a Grado, Italy., Klangkaew N; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand., Phaochoosak N; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand., Chomcheun T; Eastern Marine and Coastal Resources Research and Development Center, Rayong, Thailand., Archawakulathep A; Department of Veterinary Public Health, Faculty of Veterinary Medicine, Kasetsart University, Nakhon Pathom, Thailand., Poapolathep S; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand.
Jazyk: angličtina
Zdroj: Journal of veterinary pharmacology and therapeutics [J Vet Pharmacol Ther] 2024 Jan; Vol. 47 (1), pp. 54-59. Date of Electronic Publication: 2023 Sep 16.
DOI: 10.1111/jvp.13406
Abstrakt: The pharmacokinetics were described of meloxicam (MLX) in green sea turtles (Chelonia mydas), following a single intravenous (i.v.) and intramuscular (i.m.) administrations at one of two dosages of 0.1 or 0.2 mg/kg body weight (b.w.). The sample of 20 green sea turtles was divided into four groups (n = 5) using a randomization procedure according to a parallel study design. Blood samples were collected at pre-assigned times up to 168 h. MLX in the plasma was cleaned-up and quantified using a validated high-performance liquid chromatography method with UV detection. The concentration of MLX in the experimental green sea turtles with respect to time was pharmacokinetically analyzed using a non-compartment model. MLX plasma concentrations were quantifiable for up to 72 and 120 h after i.v. at dosages of 0.1 and 0.2 mg/kg b.w., respectively, whereas it was measurable for up to 168 h after i.m. administration at both dosages. The long elimination half-life value of MLX (28 h) obtained in green sea turtles after i.v. administration was consistent with the quite slow clearance rate for both dosages. The average maximum concentration (C max ) values of MLX were 1.05 μg/mL and 4.26 μg/mL at dosages of 0.1 and 0.2 mg/kg b.w., respectively, with their elimination half-life values being 37.26 h and 30.64 h, respectively, after i.m. administrations. The absolute i.m. bioavailability was approximately 110%. These results suggested that i.m. administration of MLX at a dosage of 0.2 mg/kg b.w. was likely to be effective for clinical use in green sea turtles (Chelonia mydas). However, further studies are needed to determine the pharmacodynamic properties and clinical efficacy of MLX for the treatment of inflammatory disease after single and multiple dosages.
(© 2023 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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