Heart failure and diabetes: Understanding the bidirectional relationship.

Autor:	Elendu C; Federal University Teaching Hospital, Owerri, Nigeria., Amaechi DC; Igbinedion University Okada, Nigeria., Elendu TC; Imo State University, Nigeria., Ashna M; University of Ottawa, Canada., Ross-Comptis J; Larkin Community Hospital, United States., Ansong SO; Catholic Hospital Battor, Ghana., Egbunu EO; Federal Medical Centre Bida, Nigeria., Okafor GC; University of Nigeria Teaching Hospital, Enugu, Nigeria., Jingwa KA; Kazan State Medical University, Russia., Akintunde AA; Babcock University, Nigeria., Ogah CM; Babcock University, Nigeria., Edeko MO; Babcock University, Nigeria., Ibitoye AV; Babcock University, Nigeria., Ogunseye MO; Nationa Pirogov Memorial Medical University, Vinnytsia, Ukraine., Alakwe-Ojimba CE; Chukwuemeka Odumegwu Ojukwu University, Nigeria., Omeludike EK; University of Port Harcourt, Nigeria., Oguine CA; Babcock University, Nigeria., Afuh RN; The Manor Hospital, Oxford, United Kingdom., Olawuni CA; General Hospital, Odan, Lagos., Ekwem OR; Delta State University, Nigeria., Oyedele BA; Babcock University, Nigeria., Pius EI; Babcock University, Nigeria., Asekhauno MO; Babcock University, Nigeria., Ladele JA; Babcock University, Nigeria., Okoro CB; Federal medical center Owerri, Nigeria., Monika Pouekoua BC; University of Bamenda, Cameroon., Adenikinju JS; Northwick Park Hospital London Northwest NHS Trust, Nigeria., Agu-Ben CM; Kharkiv Nationa Medical University, Ukraine., Aborisade O; Olabisi Onabanjo University Teaching Hospital, Nigeria.
Jazyk:	angličtina
Zdroj:	Medicine [Medicine (Baltimore)] 2023 Sep 15; Vol. 102 (37), pp. e34906.
DOI:	10.1097/MD.0000000000034906
Abstrakt:	Heart failure and diabetes mellitus are 2 common and closely intertwined chronic conditions that often coexist in individuals. The relationship between heart failure and diabetes is bidirectional, meaning that each condition can influence the development and progression of the other. Understanding this complex interplay is crucial for optimizing the management and outcomes of patients with these comorbidities. This review comprehensively analyzed the literature to examine the bidirectional relationship between heart failure and diabetes. We searched various electronic databases and included studies that explored the pathophysiological mechanisms, epidemiology, clinical implications, and therapeutic considerations associated with this relationship. The bidirectional relationship between heart failure and diabetes is multifactorial and involves several interconnected mechanisms. Diabetes is a recognized risk factor for heart failure, increasing the risk of its development and accelerating its progression. On the other hand, heart failure can contribute to the development of insulin resistance and worsen glycemic control in patients with diabetes. Shared risk factors, such as obesity, hypertension, and dyslipidemia, contribute to development of both conditions. Additionally, hyperglycemia, insulin resistance, chronic inflammation, oxidative stress, and mitochondrial dysfunction play significant roles in the pathogenesis of heart failure in individuals with diabetes. The bidirectional relationship between heart failure and diabetes has important clinical implications. Patients with heart failure and diabetes have worse outcomes, including higher hospitalization rates, morbidity, and mortality, than those without diabetes. Optimal management strategies should target both conditions simultaneously, focusing on lifestyle modifications, pharmacotherapy, glycemic control, and cardiovascular risk reduction. Competing Interests: The authors have no funding and conflicts of interest to disclose. (Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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