Association of vaccine-specific regulatory T cells with reduced antibody response to repeated influenza vaccination.

Autor: Lin PH; Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan.; Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan., Hsiao PJ; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan., Pan CF; Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan., Liu MT; Center for Diagnostics and Vaccine Development, Centers for Disease Control, Taipei, Taiwan., Wang JT; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan., Ching C; Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan., Wu FY; Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan., Lin YH; Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan., Yang YC; Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan., Hsu LY; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.; Graduate Program of Data Science, National Taiwan University and Academia Sinica, Taipei, Taiwan., Yang HC; Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Wu UI; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.; Department of Medicine, National Taiwan University Cancer Center, Taipei, Taiwan.
Jazyk: angličtina
Zdroj: European journal of immunology [Eur J Immunol] 2023 Dec; Vol. 53 (12), pp. e2350525. Date of Electronic Publication: 2023 Sep 29.
DOI: 10.1002/eji.202350525
Abstrakt: Repeated annual influenza vaccinations have been associated with reduced vaccine-induced antibody responses. This prospective study aimed to explore the role of vaccine antigen-specific regulatory T (Treg) cells in antibody response to repeated annual influenza vaccination. We analyzed pre- and postvaccination hemagglutination inhibition (HI) titers, seroconversion rates, seroprotection rates, vaccine antigen hemagglutinin (HA)-specific Treg cells, and conventional T (Tconv) cells. We compared these parameters between vaccinees with or without vaccine-induced seroconversion. Our multivariate logistic regression revealed that prior vaccination was significantly associated with a decreased likelihood of achieving seroconversion for both H1N1(adjusted OR, 0.03; 95% CI, 0.01-0.13) and H3N2 (adjusted OR, 0.09; 95% CI, 0.03-0.30). Furthermore, individuals who received repeated vaccinations had significantly higher levels of pre-existing HA-specific Treg cells than those who did not. We also found that vaccine-induced fold-increases in HI titers and seroconversion were negatively correlated with pre-existing HA-specific Treg cells and positively correlated with the ratio of Tconv to Treg cells. Overall, our findings suggest that repeated annual influenza vaccination is associated with a lower vaccine-induced antibody response and a higher frequency of vaccine-specific Treg cells. However, a lower frequency of pre-existing Treg cells correlates with a higher postvaccination antibody response.
(© 2023 Wiley-VCH GmbH.)
Databáze: MEDLINE
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