Self-assembling Gn head ferritin nanoparticle vaccine provides full protection from lethal challenge of Dabie bandavirus in aged ferrets.

Autor:	Kim D; Department of Cancer Biology, Infection Biology Program, and Global Center for Pathogen and Human Health Research, Lerner Research Institute, Cleveland Clinic , Cleveland, Ohio, USA., Kim E; College of Medicine and Medical Research Institute, Chungbuk National University , Cheongju, Republic of Korea.; Zoonotic Infectious Disease Research Center, Chungbuk National University , Cheongju, Republic of Korea.; Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Sciences , Daejeon, Republic of Korea., Kim S; College of Medicine and Medical Research Institute, Chungbuk National University , Cheongju, Republic of Korea.; Zoonotic Infectious Disease Research Center, Chungbuk National University , Cheongju, Republic of Korea.; Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Sciences , Daejeon, Republic of Korea., Chung Y; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology , Daejeon, Republic of Korea., Lai C-J; Department of Cancer Biology, Infection Biology Program, and Global Center for Pathogen and Human Health Research, Lerner Research Institute, Cleveland Clinic , Cleveland, Ohio, USA., Cha I; Department of Cancer Biology, Infection Biology Program, and Global Center for Pathogen and Human Health Research, Lerner Research Institute, Cleveland Clinic , Cleveland, Ohio, USA., Cho S-D; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology , Daejeon, Republic of Korea., Choi Y; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology , Daejeon, Republic of Korea., Dai X; Department of Physiology and Biophysics, Case Western Reserve University , Cleveland, Ohio, USA., Kim S; Department of Cancer Biology, Infection Biology Program, and Global Center for Pathogen and Human Health Research, Lerner Research Institute, Cleveland Clinic , Cleveland, Ohio, USA., Kang S; Department of Cancer Biology, Infection Biology Program, and Global Center for Pathogen and Human Health Research, Lerner Research Institute, Cleveland Clinic , Cleveland, Ohio, USA., Kwak M-J; Department of Cancer Biology, Infection Biology Program, and Global Center for Pathogen and Human Health Research, Lerner Research Institute, Cleveland Clinic , Cleveland, Ohio, USA., Liu Z; Department of Cancer Biology, Infection Biology Program, and Global Center for Pathogen and Human Health Research, Lerner Research Institute, Cleveland Clinic , Cleveland, Ohio, USA., Choi Y; Florida Research and Innovation Center, Cleveland Clinic , Port St. Lucie, Florida, USA., Park S-H; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology , Daejeon, Republic of Korea., Choi YK; College of Medicine and Medical Research Institute, Chungbuk National University , Cheongju, Republic of Korea.; Zoonotic Infectious Disease Research Center, Chungbuk National University , Cheongju, Republic of Korea.; Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Sciences , Daejeon, Republic of Korea., Jung JU; Department of Cancer Biology, Infection Biology Program, and Global Center for Pathogen and Human Health Research, Lerner Research Institute, Cleveland Clinic , Cleveland, Ohio, USA.
Jazyk:	angličtina
Zdroj:	MBio [mBio] 2023 Oct 31; Vol. 14 (5), pp. e0186823. Date of Electronic Publication: 2023 Sep 15.
DOI:	10.1128/mbio.01868-23
Abstrakt:	Importance: Dabie bandavirus (DBV) is an emerging tick-borne virus that causes severe fever with thrombocytopenia syndrome (SFTS) in infected patients. Human SFTS symptoms progress from fever, fatigue, and muscle pain to the depletion of white blood cells and platelets with fatality rates up to 30%. The recent spread of its vector tick to over 20 states in the United States increases the potential for outbreaks of the SFTS beyond the East Asia. Thus, the development of vaccine to control this rapidly emerging virus is a high priority. In this study, we applied self-assembling ferritin (FT) nanoparticle to enhance the immunogenicity of DBV Gn head domain (GnH) as a vaccine target. Mice immunized with the GnH-FT nanoparticle vaccine induced potent antibody responses and cellular immunity. Immunized aged ferrets were fully protected from the lethal challenge of DBV. Our study describes the GnH-FT nanoparticle vaccine candidate that provides protective immunity against the emerging DBV infection. Competing Interests: A patent for the presented DBV GnH-ferritin nanoparticle is filed via Cleveland Clinic Foundation Innovations Office.
Databáze:	MEDLINE
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