Radiation-Induced Transfer of Charge, Atoms, and Energy within Isolated Biomolecular Systems.

Autor: Chevalier F; CIMAP UMR 6252, CEA/CNRS/ENSICAEN/Université de Caen Normandie, Bd Becquerel, 14070, Caen, France., Schlathölter T; Zernike Institute for Advanced Materials, University of Groningen, Groningen (The, Netherlands.; University College Groningen, University of Groningen, Groningen (The, Netherlands., Poully JC; CIMAP UMR 6252, CEA/CNRS/ENSICAEN/Université de Caen Normandie, Bd Becquerel, 14070, Caen, France.
Jazyk: angličtina
Zdroj: Chembiochem : a European journal of chemical biology [Chembiochem] 2023 Nov 16; Vol. 24 (22), pp. e202300543. Date of Electronic Publication: 2023 Sep 28.
DOI: 10.1002/cbic.202300543
Abstrakt: In biological tissues, ionizing radiation interacts with a variety of molecules and the consequences include cell killing and the modification of mechanical properties. Applications of biological radiation action are for instance radiotherapy, sterilization, or the tailoring of biomaterial properties. During the first femtoseconds to milliseconds after the initial radiation action, biomolecular systems typically respond by transfer of charge, atoms, or energy. In the condensed phase, it is usually very difficult to distinguish direct effects from indirect effects. A straightforward solution for this problem is the use of gas-phase techniques, for instance from the field of mass spectrometry. In this review, we survey mainly experimental but also theoretical work, focusing on radiation-induced intra- and inter-molecular transfer of charge, atoms, and energy within biomolecular systems in the gas phase. Building blocks of DNA, proteins, and saccharides, but also antibiotics are considered. The emergence of general processes as well as their timescales and mechanisms are highlighted.
(© 2023 Wiley-VCH GmbH.)
Databáze: MEDLINE
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