A lamprey neural cell type atlas illuminates the origins of the vertebrate brain.

Autor: Lamanna F; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany. f.lamanna@zmbh.uni-heidelberg.de., Hervas-Sotomayor F; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany. f.hervas@zmbh.uni-heidelberg.de., Oel AP; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany.; Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Jandzik D; Department of Ecology and Evolutionary Biology, University of Colorado Boulder, Boulder, CO, USA.; Department of Zoology, Comenius University, Bratislava, Slovakia., Sobrido-Cameán D; Department of Functional Biology, CIBUS, Faculty of Biology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain., Santos-Durán GN; Department of Functional Biology, CIBUS, Faculty of Biology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain., Martik ML; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA., Stundl J; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Green SA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Brüning T; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany., Mößinger K; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany., Schmidt J; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany., Schneider C; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany., Sepp M; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany., Murat F; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany.; INRAE, LPGP, Rennes, France., Smith JJ; Department of Biology, University of Kentucky, Lexington, KY, USA., Bronner ME; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Rodicio MC; Department of Functional Biology, CIBUS, Faculty of Biology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain., Barreiro-Iglesias A; Department of Functional Biology, CIBUS, Faculty of Biology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain., Medeiros DM; Department of Ecology and Evolutionary Biology, University of Colorado Boulder, Boulder, CO, USA., Arendt D; Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Kaessmann H; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany. h.kaessmann@zmbh.uni-heidelberg.de.
Jazyk: angličtina
Zdroj: Nature ecology & evolution [Nat Ecol Evol] 2023 Oct; Vol. 7 (10), pp. 1714-1728. Date of Electronic Publication: 2023 Sep 14.
DOI: 10.1038/s41559-023-02170-1
Abstrakt: The vertebrate brain emerged more than ~500 million years ago in common evolutionary ancestors. To systematically trace its cellular and molecular origins, we established a spatially resolved cell type atlas of the entire brain of the sea lamprey-a jawless species whose phylogenetic position affords the reconstruction of ancestral vertebrate traits-based on extensive single-cell RNA-seq and in situ sequencing data. Comparisons of this atlas to neural data from the mouse and other jawed vertebrates unveiled various shared features that enabled the reconstruction of cell types, tissue structures and gene expression programs of the ancestral vertebrate brain. However, our analyses also revealed key tissues and cell types that arose later in evolution. For example, the ancestral brain was probably devoid of cerebellar cell types and oligodendrocytes (myelinating cells); our data suggest that the latter emerged from astrocyte-like evolutionary precursors in the jawed vertebrate lineage. Altogether, our work illuminates the cellular and molecular architecture of the ancestral vertebrate brain and provides a foundation for exploring its diversification during evolution.
(© 2023. The Author(s).)
Databáze: MEDLINE
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