Distinct monkeypox virus lineages co-circulating in humans before 2022.

Autor: Ndodo N; Nigeria Centre for Disease Control, Abuja, Nigeria., Ashcroft J; UK Public Health Rapid Support Team, UK Health Security Agency/London School of Hygiene & Tropical Medicine, London, UK., Lewandowski K; UK Health Security Agency, Research & Evaluation Services, Porton Down, UK., Yinka-Ogunleye A; Nigeria Centre for Disease Control, Abuja, Nigeria., Chukwu C; Nigeria Centre for Disease Control, Abuja, Nigeria., Ahmad A; Nigeria Centre for Disease Control, Abuja, Nigeria., King D; CBR Division, Defence Science and Technology Laboratory, Salisbury, UK., Akinpelu A; Nigeria Centre for Disease Control, Abuja, Nigeria., Maluquer de Motes C; Department of Microbial Sciences, School of Biosciences and Medicine, University of Surrey, Guildford, UK., Ribeca P; UK Health Security Agency, London, UK.; Biomathematics and Statistics Scotland, Edinburgh, UK., Sumner RP; Department of Microbial Sciences, School of Biosciences and Medicine, University of Surrey, Guildford, UK., Rambaut A; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK., Chester M; CBR Division, Defence Science and Technology Laboratory, Salisbury, UK., Maishman T; CBR Division, Defence Science and Technology Laboratory, Salisbury, UK., Bamidele O; Nigeria Centre for Disease Control, Abuja, Nigeria., Mba N; Nigeria Centre for Disease Control, Abuja, Nigeria., Babatunde O; Nigeria Centre for Disease Control, Abuja, Nigeria., Aruna O; UK Health Security Agency, International Health Regulations (IHR) Strengthening Project, British High Commission, Abuja, Nigeria., Pullan ST; UK Health Security Agency, Research & Evaluation Services, Porton Down, UK., Gannon B; UK Public Health Rapid Support Team, UK Health Security Agency/London School of Hygiene & Tropical Medicine, London, UK., Brown CS; UK Health Security Agency, London, UK., Ihekweazu C; Nigeria Centre for Disease Control, Abuja, Nigeria., Adetifa I; Nigeria Centre for Disease Control, Abuja, Nigeria., Ulaeto DO; CBR Division, Defence Science and Technology Laboratory, Salisbury, UK. dulaeto@mail.dstl.gov.uk.
Jazyk: angličtina
Zdroj: Nature medicine [Nat Med] 2023 Sep; Vol. 29 (9), pp. 2317-2324. Date of Electronic Publication: 2023 Sep 14.
DOI: 10.1038/s41591-023-02456-8
Abstrakt: The 2022 global mpox outbreak raises questions about how this zoonotic disease established effective human-to-human transmission and its potential for further adaptation. The 2022 outbreak virus is related to an ongoing outbreak in Nigeria originally reported in 2017, but the evolutionary path linking the two remains unclear due to a lack of genomic data between 2018, when virus exportations from Nigeria were first recorded, and 2022, when the global mpox outbreak began. Here, 18 viral genomes obtained from patients across southern Nigeria in 2019-2020 reveal multiple lineages of monkeypox virus (MPXV) co-circulated in humans for several years before 2022, with progressive accumulation of mutations consistent with APOBEC3 activity over time. We identify Nigerian A.2 lineage isolates, confirming the lineage that has been multiply exported to North America independently of the 2022 outbreak originated in Nigeria, and that it has persisted by human-to-human transmission in Nigeria for more than 2 years before its latest exportation. Finally, we identify a lineage-defining APOBEC3-style mutation in all A.2 isolates that disrupts gene A46R, encoding a viral innate immune modulator. Collectively, our data demonstrate MPXV capacity for sustained diversification within humans, including mutations that may be consistent with established mechanisms of poxvirus adaptation.
(© 2023. Crown.)
Databáze: MEDLINE
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