Pre-activated nanoparticles with persistent luminescence for deep tumor photodynamic therapy in gallbladder cancer.

Autor: Juengpanich S; Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China.; School of Medicine, Zhejiang University, 310058, Hangzhou, China.; National Engineering Research Center of Innovation and Application of Minimally Invasive Instruments, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China., Li S; Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China.; School of Medicine, Zhejiang University, 310058, Hangzhou, China., Yang T; Department of Chemistry, Zhejiang Sci-Tech University, 310018, Hangzhou, China., Xie T; Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China.; School of Medicine, Zhejiang University, 310058, Hangzhou, China., Chen J; Department of Chemistry, Zhejiang University, 310016, Hangzhou, China., Shan Y; Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China., Lee J; Zhejiang Provincial Key Laboratory for Advanced Drug Delivery Systems, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, China., Lu Z; Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China., Chen T; Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China., Zhang B; Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China., Cao J; Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China., Hu J; Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China., Yu J; Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China.; Zhejiang Provincial Key Laboratory for Advanced Drug Delivery Systems, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, China.; National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, 310058, Hangzhou, China.; Liangzhu Laboratory, Zhejiang University Medical Center, 311121, Hangzhou, China.; Jinhua Institute of Zhejiang University, 321299, Jinhua, China., Wang Y; Zhejiang Provincial Key Laboratory for Advanced Drug Delivery Systems, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, China., Topatana W; Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China. win.topatana@zju.edu.cn.; School of Medicine, Zhejiang University, 310058, Hangzhou, China. win.topatana@zju.edu.cn., Gu Z; Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China. guzhen@zju.edu.cn.; Zhejiang Provincial Key Laboratory for Advanced Drug Delivery Systems, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, China. guzhen@zju.edu.cn.; National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, 310058, Hangzhou, China. guzhen@zju.edu.cn.; Liangzhu Laboratory, Zhejiang University Medical Center, 311121, Hangzhou, China. guzhen@zju.edu.cn.; Jinhua Institute of Zhejiang University, 321299, Jinhua, China. guzhen@zju.edu.cn.; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, 310027, Hangzhou, China. guzhen@zju.edu.cn., Cai X; Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China. srrsh_cxj@zju.edu.cn.; School of Medicine, Zhejiang University, 310058, Hangzhou, China. srrsh_cxj@zju.edu.cn.; National Engineering Research Center of Innovation and Application of Minimally Invasive Instruments, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China. srrsh_cxj@zju.edu.cn., Chen M; Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China. mychen@zju.edu.cn.; School of Medicine, Zhejiang University, 310058, Hangzhou, China. mychen@zju.edu.cn.; National Engineering Research Center of Innovation and Application of Minimally Invasive Instruments, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China. mychen@zju.edu.cn.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 Sep 14; Vol. 14 (1), pp. 5699. Date of Electronic Publication: 2023 Sep 14.
DOI: 10.1038/s41467-023-41389-1
Abstrakt: Phototherapy of deep tumors still suffers from many obstacles, such as limited near-infrared (NIR) tissue penetration depth and low accumulation efficiency within the target sites. Herein, stimuli-sensitive tumor-targeted photodynamic nanoparticles (STPNs) with persistent luminescence for the treatment of deep tumors are reported. Purpurin 18 (Pu18), a porphyrin derivative, is utilized as a photosensitizer to produce persistent luminescence in STPNs, while lanthanide-doped upconversion nanoparticles (UCNPs) exhibit bioimaging properties and possess high photostability that can enhance photosensitizer efficacy. STPNs are initially stimulated by NIR irradiation before intravenous administration and accumulate at the tumor site to enter the cells through the HER2 receptor. Due to Pu18 afterglow luminescence properties, STPNs can continuously generate ROS to inhibit NFκB nuclear translocation, leading to tumor cell apoptosis. Moreover, STPNs can be used for diagnostic purposes through MRI and intraoperative NIR navigation. STPNs exceptional antitumor properties combined the advantages of UCNPs and persistent luminescence, representing a promising phototherapeutic strategy for deep tumors.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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