A Wearable Touch-Activated Device Integrated with Hollow Microneedles for Continuous Sampling and Sensing of Dermal Interstitial Fluid.

Autor: Abbasiasl T; Department of Biomedical Sciences and Engineering, Koç University, Rumelifeneri Yolu, Sarıyer, Istanbul, 34450, Turkey., Mirlou F; Department of Biomedical Sciences and Engineering, Koç University, Rumelifeneri Yolu, Sarıyer, Istanbul, 34450, Turkey., Mirzajani H; Department of Mechanical Engineering, Koç University, Rumelifeneri Yolu, Sarıyer, Istanbul, 34450, Turkey., Bathaei MJ; Department of Biomedical Sciences and Engineering, Koç University, Rumelifeneri Yolu, Sarıyer, Istanbul, 34450, Turkey., Istif E; Faculty of Engineering and Natural Sciences, Kadir Has University, Cibali, Istanbul, 34083, Turkey., Shomalizadeh N; Koç University Research Center for Translational Research (KUTTAM), Koç University, Rumelifeneri Yolu, Sarıyer, Istanbul, 34450, Turkey., Cebecioğlu RE; Department of Biomedical Sciences and Engineering, Koç University, Rumelifeneri Yolu, Sarıyer, Istanbul, 34450, Turkey., Özkahraman EE; Department of Material Science and Engineering, Koç University, Rumelifeneri Yolu, Sarıyer, Istanbul, 34450, Turkey., Yener UC; Department of Mechanical Engineering, Koç University, Rumelifeneri Yolu, Sarıyer, Istanbul, 34450, Turkey., Beker L; Department of Biomedical Sciences and Engineering, Koç University, Rumelifeneri Yolu, Sarıyer, Istanbul, 34450, Turkey.; Department of Mechanical Engineering, Koç University, Rumelifeneri Yolu, Sarıyer, Istanbul, 34450, Turkey.; Koç University Research Center for Translational Research (KUTTAM), Koç University, Rumelifeneri Yolu, Sarıyer, Istanbul, 34450, Turkey.; Nanofabrication and Nanocharacterization Center for Scientific and Technological Advanced Research (n2Star), Koç University, Rumelifeneri Yolu, Sarıyer, Istanbul, 34450, Turkey.
Jazyk: angličtina
Zdroj: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2024 Jan; Vol. 36 (2), pp. e2304704. Date of Electronic Publication: 2023 Nov 23.
DOI: 10.1002/adma.202304704
Abstrakt: Dermal interstitial fluid (ISF) is emerging as a rich source of biomarkers that complements conventional biofluids such as blood and urine. However, the impact of ISF sampling in clinical applications has been limited owing to the challenges associated with extraction. The implementation of microneedle-based wearable devices that can extract dermal ISF in a pain-free and easy-to-use manner has attracted growing attention in recent years. Here, a fully integrated touch-activated wearable device based on a laser-drilled hollow microneedle (HMN) patch for continuous sampling and sensing of dermal ISF is introduced. The developed platform can produce and maintain the required vacuum pressure (as low as ≈ -53 kPa) to collect adequate volumes of ISF (≈2 µL needle -1 h -1 ) for medical applications. The vacuum system can be activated through a one-touch finger operation. A parametric study is performed to investigate the effect of microneedle array size, vacuum pressure, and extraction duration on collected ISF. The capability of the proposed platform for continuous health monitoring is further demonstrated by the electrochemical detection of glucose and pH levels of ISF in animal models. This HMN-based system provides an alternative tool to the existing invasive techniques for ISF collection and sensing for medical diagnosis and treatment.
(© 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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