Injecting hyaluronan in the thoracolumbar fascia: A model study.

Autor: Nešporová K; Contipro a.s., Dolní Dobrouč 401, 561 02 Dolní Dobrouč, Czech Republic. Electronic address: kristina.nesporova@contipro.com., Matonohová J; Contipro a.s., Dolní Dobrouč 401, 561 02 Dolní Dobrouč, Czech Republic., Husby J; Contipro a.s., Dolní Dobrouč 401, 561 02 Dolní Dobrouč, Czech Republic., Toropitsyn E; Contipro a.s., Dolní Dobrouč 401, 561 02 Dolní Dobrouč, Czech Republic., Stupecká LD; Contipro a.s., Dolní Dobrouč 401, 561 02 Dolní Dobrouč, Czech Republic., Husby A; Contipro a.s., Dolní Dobrouč 401, 561 02 Dolní Dobrouč, Czech Republic., Suchánková Kleplová T; Department of Dentistry, Charles University, Faculty of Medicine in Hradec Kralove and University Hospital Hradec Kralove, 500 05 Hradec Kralové, Czech Republic., Streďanská A; Biotribology Research Group, Faculty of Mechanical Engineering, Brno University of Technology, 616 69 Brno, Czech Republic., Šimek M; Contipro a.s., Dolní Dobrouč 401, 561 02 Dolní Dobrouč, Czech Republic., Nečas D; Biotribology Research Group, Faculty of Mechanical Engineering, Brno University of Technology, 616 69 Brno, Czech Republic., Vrbka M; Biotribology Research Group, Faculty of Mechanical Engineering, Brno University of Technology, 616 69 Brno, Czech Republic., Schleip R; DIPLOMA Hochschule, 37242 Bad Sooden-Allendorf, Germany; Conservative and Rehabilitative Orthopedics, Department of Sport and Health Sciences, Technical University of Munich, 80333 Munich, Germany., Velebný V; Contipro a.s., Dolní Dobrouč 401, 561 02 Dolní Dobrouč, Czech Republic.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2023 Dec 31; Vol. 253 (Pt 3), pp. 126879. Date of Electronic Publication: 2023 Sep 12.
DOI: 10.1016/j.ijbiomac.2023.126879
Abstrakt: Hyaluronan (HA) has been recently identified as a key component of the densification of thoracolumbar fascia (TLF), a potential contributor to non-specific lower back pain (LBP) currently treated with manual therapy and systemic or local delivery of anti-inflammatory drugs. The aim of this study was to establish a novel animal model suitable for studying ultrasound-guided intrafascial injection prepared from HA with low and high Mw. Effects of these preparations on the profibrotic switch and mechanical properties of TLF were measured by qPCR and rheology, respectively, while their lubricating properties were evaluated by tribology. Rabbit proved to be a suitable model of TLF physiology due to its manageable size enabling both TLF extraction and in situ intrafascial injection. Surprisingly, the tribology showed that low Mw HA was a better lubricant than the high Mw HA. It was also better suited for intrafascial injection due to its lower injection force and ability to freely spread between TLF layers. No profibrotic effects of either HA preparation in the TLF were observed. The intrafascial application of HA with lower MW into the TLF appears to be a promising way how to increase the gliding of the fascial layers and target the myofascial LBP.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Robert Schleip reports a relationship with Contipro a.s. that includes: consulting or advisory and paid expert testimony. Vladimir Velebny reports a relationship with Contipro a.s. that includes: board membership and equity or stocks.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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