Exposure to Agent Orange is associated with increased recurrence after surgical treatment of stage I non-small cell lung cancer.

Autor:	Subramanian MP; Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Mo. Electronic address: m.p.subramanian@wustl.edu., Eaton DB Jr; Veterans Affairs St Louis Health Care System, St Louis, Mo., Labilles UL; Veterans Affairs St Louis Health Care System, St Louis, Mo., Heiden BT; Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Mo., Chang SH; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, Mo., Yan Y; Veterans Affairs St Louis Health Care System, St Louis, Mo; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, Mo., Schoen MW; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, Mo; Division of Hematology and Medical Oncology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Mo., Patel MR; Veterans Affairs St Louis Health Care System, St Louis, Mo., Kreisel D; Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Mo., Nava RG; Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Mo., Thomas TS; Department of Medical Oncology, Washington University School of Medicine, St Louis, Mo., Meyers BF; Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Mo., Kozower BD; Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Mo., Puri V; Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Mo.
Jazyk:	angličtina
Zdroj:	The Journal of thoracic and cardiovascular surgery [J Thorac Cardiovasc Surg] 2024 May; Vol. 167 (5), pp. 1591-1600.e2. Date of Electronic Publication: 2023 Sep 12.
DOI:	10.1016/j.jtcvs.2023.09.013
Abstrakt:	Objective: Approximately 3 million Americans served in the armed forces during the Vietnam War. Veterans have a higher incidence rate of lung cancer compared with the general population, which may be related to exposures sustained during service. Agent Orange, one of the tactical herbicides used by the armed forces as a means of destroying crops and clearing vegetation, has been linked to the development of several cancers including non-small cell lung cancer. However, traditional risk models of lung cancer survival and recurrence often do not include such exposures. We aimed to examine the relationship between Agent Orange exposure and overall survival and disease recurrence for surgically treated stage I non-small cell lung cancer. Methods: We performed a retrospective cohort study using a uniquely compiled dataset of US Veterans with pathologic I non-small cell lung cancer. We included adult patients who served in the Vietnam War and underwent surgical resection between 2010 and 2016. Our 2 comparison groups included those with identified Agent Orange exposure and those who were unexposed. We used multivariable Cox proportional hazards and Fine and Gray competing risk analyses to examine overall survival and disease recurrence for patients with pathologic stage I disease, respectively. Results: A total of 3958 Vietnam Veterans with pathologic stage I disease were identified (994 who had Agent Orange exposure and 2964 who were unexposed). Those who had Agent Orange exposure were more likely to be male, to be White, and to live a further distance from their treatment facility (P < .05). Tumor size distribution, grade, and histology were similar between cohorts. Multivariable Cox proportional hazards modeling identified similar overall survival between cohorts (Agent Orange exposure hazard ratio, 0.97; 95% CI, 0.86-1.09). Patients who had Agent Orange exposure had a 19% increased risk of disease recurrence (hazard ratio, 1.19; 95% CI, 1.02-1.40). Conclusions: Veterans with known Agent Orange exposure who undergo surgical treatment for stage I non-small cell lung cancer have an approximately 20% increased risk of disease recurrence compared with their nonexposed counterparts. Agent Orange exposure should be taken into consideration when determining treatment and surveillance regimens for Veteran patients. (Copyright © 2023. Published by Elsevier Inc.)
Databáze:	MEDLINE
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