Somatostatin receptor subtype expression and radiomics from DWI-MRI represent SUV of [68Ga]Ga-DOTATOC PET in patients with meningioma.

Autor: Iglseder S; Department of Neurology, Innsbruck Medical University, Innsbruck, Austria., Iglseder A; Department of Geodesy and Geoinformation, Technical University Vienna, Vienna, Austria., Beliveau V; Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.; Neuroimaging Research Core Facility, Innsbruck Medical University, Innsbruck, Austria., Heugenhauser J; Department of Neurology, Innsbruck Medical University, Innsbruck, Austria., Gizewski ER; Neuroimaging Research Core Facility, Innsbruck Medical University, Innsbruck, Austria.; Department of Neuroradiology, Innsbruck Medical University, Innsbruck, Austria., Kerschbaumer J; Department of Neurosurgery, Innsbruck Medical University, Innsbruck, Austria., Stockhammer G; Department of Neurology, Innsbruck Medical University, Innsbruck, Austria., Uprimny C; Department of Nuclear Medicine, Innsbruck Medical University, Innsbruck, Austria., Virgolini I; Department of Nuclear Medicine, Innsbruck Medical University, Innsbruck, Austria., Dudas J; Department of Otorhinolaryngology, Innsbruck Medical University, Innsbruck, Austria., Nevinny-Stickel M; Department of Therapeutic Radiology and Oncology, Innsbruck Medical University, Innsbruck, Austria., Nowosielski M; Department of Neurology, Innsbruck Medical University, Innsbruck, Austria. Martha.Nowosielski@i-med.ac.at., Scherfler C; Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.; Department of Neuroradiology, Innsbruck Medical University, Innsbruck, Austria.
Jazyk: angličtina
Zdroj: Journal of neuro-oncology [J Neurooncol] 2023 Sep; Vol. 164 (3), pp. 711-720. Date of Electronic Publication: 2023 Sep 14.
DOI: 10.1007/s11060-023-04414-3
Abstrakt: Objective: This retrospective study aimed to analyse the correlation between somatostatin receptor subtypes (SSTR 1-5) and maximum standardized uptake value (SUV max ) in meningioma patients using Gallium-68 DOTA-D-Phe1-Tyr3-octreotide Positron Emission Tomography ([68Ga]Ga-DOTATOC PET). Secondly, we developed a radiomic model based on apparent diffusion coefficient (ADC) maps derived from diffusion weighted magnetic resonance images (DWI MRI) to reproduce SUV max .
Method: The study included 51 patients who underwent MRI and [68Ga]Ga-DOTATOC PET before meningioma surgery. SUV max values were quantified from PET images and tumour areas were segmented on post-contrast T1-weighted MRI and mapped to ADC maps. A total of 1940 radiomic features were extracted from the tumour area on each ADC map. A random forest regression model was trained to predict SUV max and the model's performance was evaluated using repeated nested cross-validation. The expression of SSTR subtypes was quantified in 18 surgical specimens and compared to SUV max values.
Results: The random forest regression model successfully predicted SUV max values with a significant correlation observed in all 100 repeats (p < 0.05). The mean Pearson's r was 0.42 ± 0.07 SD, and the root mean square error (RMSE) was 28.46 ± 0.16. SSTR subtypes 2A, 2B, and 5 showed significant correlations with SUV max values (p < 0.001, R2 = 0.669; p = 0.001, R2 = 0.393; and p = 0.012, R2 = 0.235, respectively).
Conclusion: SSTR subtypes 2A, 2B, and 5 correlated significantly with SUV max in meningioma patients. The developed radiomic model based on ADC maps effectively reproduces SUV max using [68Ga]Ga-DOTATOC PET.
(© 2023. The Author(s).)
Databáze: MEDLINE
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