Birth Defects in Offspring of Adolescent and Young Adults with a History of Cancer: A Population-Based Study of 27,000 Women.

Autor:	Murphy CC; Department of Health Promotion & Behavioral Sciences, UTHealth Houston School of Public Health, Houston, Texas., Betts AC; Department of Health Promotion & Behavioral Sciences, UTHealth Houston School of Public Health, Houston, Texas., Pruitt SL; Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, Texas.; Harold C. Simmons Comprehensive Cancer Center, Dallas, Texas., Cohn BA; Child Health and Development Studies, Public Health Institute, Berkeley, California., Shay LA; Department of Health Promotion & Behavioral Sciences, UTHealth Houston School of Public Health, Houston, Texas., Allicock MA; Department of Health Promotion & Behavioral Sciences, UTHealth Houston School of Public Health, Houston, Texas., Wang JS; Department of Epidemiology, Human Genetics and Environmental Sciences, UTHealth Houston School of Public Health, Houston, Texas., Lupo PJ; Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Jazyk:	angličtina
Zdroj:	Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2023 Dec 01; Vol. 32 (12), pp. 1699-1706.
DOI:	10.1158/1055-9965.EPI-23-0743
Abstrakt:	Background: We examined birth defects in offspring of adolescent and young adult (AYA) women with a history of cancer (age 15-39 years at diagnosis). Methods: We identified AYA women diagnosed with cancer between January 1, 1999, and December 31, 2015 using population-based data from the Texas Cancer Registry; data were linked with live birth and fetal death certificates through December 31, 2016 to identify singleton births to AYA women after diagnosis. Birth defects in offspring through age 12 months were ascertained from the Texas Birth Defects Registry. We estimated risk of birth defects in offspring of AYA women and women without cancer (matched 3:1 by maternal race/ethnicity, maternal age, and offspring year of birth) and compared risk using log binomial regression models. Results: There were 6,882 singleton births to AYA women after diagnosis. Common cancer types were thyroid (28.9%), lymphoma (12.5%), and breast (10.7%). Risk of any birth defect was higher in offspring of AYA women (6.0%) compared with offspring of women without cancer [n = 20,646; 4.8%; risk ratio (RR) 1.24; 95% confidence interval (CI), 1.11-1.38]. Risk of eye or ear (RR, 1.39; 95% CI, 1.03-1.90), heart and circulatory (RR, 1.32; 95% CI, 1.09-1.60), genitourinary (RR, 1.38; 95% CI, 1.12-1.69), and musculoskeletal (RR, 1.37; 95% CI, 1.13-1.66) defects was also higher. Conclusions: Risk of birth defects was elevated in liveborn and stillborn offspring of AYA women. Impact: Although birth defects are rare, AYA women making decisions about pregnancy and prenatal care should receive appropriate counseling and surveillance. (©2023 American Association for Cancer Research.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu