[Bacteriophages in complex treatment of septic diseases of the hand].

Autor:	Lipatov KV; Sechenov First Moscow State Medical University, Moscow, Russia., Asatryan AG; Yudin Moscow City Clinical Hospital, Moscow, Russia., Melkonyan GG; Hospital for War Veterans No. 3, Moscow, Russia.; Russian Medical Academy of Continuous Professional Education, Moscow, Russia., Kazantsev AD; Sechenov First Moscow State Medical University, Moscow, Russia., Burmistrova EN; Yudin Moscow City Clinical Hospital, Moscow, Russia., Gorbacheva IV; Sechenov First Moscow State Medical University, Moscow, Russia., Egorova DO; Sechenov First Moscow State Medical University, Moscow, Russia., Sarkisyan IP; Sechenov First Moscow State Medical University, Moscow, Russia.
Jazyk:	ruština
Zdroj:	Khirurgiia [Khirurgiia (Mosk)] 2023 (9), pp. 45-52.
DOI:	10.17116/hirurgia202309145
Abstrakt:	Objective: To evaluate the effectiveness of bacteriophages in complex surgical treatment of septic diseases of the hand. Material and Methods: We analyzed treatment outcomes in 111 patients with septic diseases of the hand (septic arthritis, tendovaginitis, phlegmon). Surgical treatment was finished by primary sutures and drainage. They were divided into two groups. Bacteriophages were used in the main group. Other components of treatment were identical. «Pyobacteriophage complex» was injected into drainage tubes during dressings. Effectiveness of treatment was evaluated considering elimination of septic process, bacterial flora and healing of surgical wound. In addition, we performed in vitro testing of microorganisms for sensitivity to Pyobacteriophage. Results: Staphylococcus and Streptococcus genus prevailed in hand infections. Pasteurella multocida has been isolated after pet bites. Growth of microflora in drainage tubes was observed in 16.7% and 21.1% of cases, respectively ( p =0.02). Wound healing via primary intention was found in 83.6% and 71.4%, respectively ( p =0.03). When testing in vitro, we observed lysis of cultures of Staphylococcus aureus in 83.6% of cases, Streptococcus pyogenes - in 33.3% of cases. Conclusion: «Pyobacteriophage complex» was effective for septic diseases of the hand. However, its partial lytic activity against the most common pathogens makes it advisable to combine phages and antibiotic therapy. Systematic renewal of phages is important due to widespread resistance of bacteria.
Databáze:	MEDLINE
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