Quality control, phytochemical profile, and biological activities of Crataegus monogyna Jacq. and Crataegus laciniata Ucria fruits aqueous extracts.

Autor:	Zahrae Radi F; Research Team of Chemistry of Bioactive Molecules and the Environment, Laboratory of Innovative Materials and Biotechnology of Natural Resources, Faculty of Sciences, Moulay Ismail University of Meknes, B.P. 11201 Zitoune, Meknes 50070, Morocco., Bencheikh N; Laboratory of Bioressources, Biotechnology, Ethnopharmacology and Health, Department of Biology, Faculty of Sciences, University Mohammed First, Boulevard Mohamed VI BP 717, Oujda 60000, Morocco., Anarghou H; Laboratory of Biological Engineering, Team of Functional and Pathological Biology, University Sultan Moulay Slimane, Faculty of Sciences and Technology, Beni Mellal, Morocco., Bouhrim M; Laboratory of Biological Engineering, Team of Functional and Pathological Biology, University Sultan Moulay Slimane, Faculty of Sciences and Technology, Beni Mellal, Morocco.; Laboratories TBC, Laboratory of Pharmacology, Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy, University of Lille, Lille, France., Alqahtani AS; Department of Pharmacognosy, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia., Hawwal MF; Department of Pharmacognosy, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia., Noman OM; Department of Pharmacognosy, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia., Bnouham M; Laboratory of Bioressources, Biotechnology, Ethnopharmacology and Health, Department of Biology, Faculty of Sciences, University Mohammed First, Boulevard Mohamed VI BP 717, Oujda 60000, Morocco., Zair T; Research Team of Chemistry of Bioactive Molecules and the Environment, Laboratory of Innovative Materials and Biotechnology of Natural Resources, Faculty of Sciences, Moulay Ismail University of Meknes, B.P. 11201 Zitoune, Meknes 50070, Morocco.
Jazyk:	angličtina
Zdroj:	Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society [Saudi Pharm J] 2023 Oct; Vol. 31 (10), pp. 101753. Date of Electronic Publication: 2023 Aug 23.
DOI:	10.1016/j.jsps.2023.101753
Abstrakt:	The current study aimed to evaluate the phytochemical composition, quality control, and antioxidant, antibacterial, antifungal, antihyperglycemic activities, and toxicity assessment of Crataegus monogyna Jacq ( C. monogyna ) and Crataegus laciniata Ucria ( C. laciniata) fruits aqueous extracts. The quality control of the plant material revealed that it is free of heavy metals and the acidity and ash parameters comply with international standards. HPLC-DAD analysis revealed the presence of eight phenolic compounds in the C. monogyna extract and nine compounds in the C. laciniata extract, with coumaric acid present only in the C. laciniata extract. According to the findings, both extracts are high in total polyphenols, total flavonoids, and condensed tannins. The results of the antioxidant activity revealed that our extracts have significant effects against 2, 2-diphényl 1-picrylhydrazyle (DPPH), and Ferric Reducing Antioxidant Power (FRAP). The antibacterial test revealed that the two extracts tested were effective against four bacterial strains, including Staphylococcus aureus , Escherichia coli , Enterobacter cloacae , and Shigella dysenteria , but were ineffective against Salmonella typhi , and Acinetobacter baumanii . In addition, extracts from both plants showed remarkable antihyperglycemic activity with no acute toxicity. In conclusion, the extracts studied could be a good source of bioactive molecules with antioxidant, antimicrobial, and anti-diabetic activity for pharmaceutical applications. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Author(s).)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu