Evaluation and monitoring of eye findings in children exposed to Zika virus during gestation: 3 years of follow-up.

Autor:	Dos Santos MLB; Faculdade de Medicina, Universidade Federal Fluminense Rua Marquês de Paraná, 303, Centro, Niterói, RJ 24.033-900, Brazil., Lima LCSS; Faculdade de Medicina, Universidade Federal Fluminense Rua Marquês de Paraná, 303, Centro, Niterói, RJ 24.033-900, Brazil., Zin AA; Instituto Fernandes Figueira, Unidade de Pesquisa Clínica Av Rui Barbosa, 716, Flamengo, Rio de Janeiro, RJ 22.250-020, Brazil., Moreira MEL; Instituto Fernandes Figueira, Unidade de Pesquisa Clínica Av Rui Barbosa, 716, Flamengo, Rio de Janeiro, RJ 22.250-020, Brazil., De Vasconcelos ZFM; Instituto Fernandes Figueira, Unidade de Pesquisa Clínica Av Rui Barbosa, 716, Flamengo, Rio de Janeiro, RJ 22.250-020, Brazil., Neves LMA; Instituto Fernandes Figueira, Unidade de Pesquisa Clínica Av Rui Barbosa, 716, Flamengo, Rio de Janeiro, RJ 22.250-020, Brazil., Pereira MB; Faculdade de Medicina, Universidade Federal Fluminense Rua Marquês de Paraná, 303, Centro, Niterói, RJ 24.033-900, Brazil., Vianna RAO; Faculdade de Medicina, Universidade Federal Fluminense Rua Marquês de Paraná, 303, Centro, Niterói, RJ 24.033-900, Brazil., Velarde LGC; Instituto de Matemática e Estatística, Universidade Federal Fluminense Rua Mário Santos Braga, s/n, Centro, Niterói, RJ 24.020-110, Brazil., De Oliveira SA; Faculdade de Medicina, Universidade Federal Fluminense Rua Marquês de Paraná, 303, Centro, Niterói, RJ 24.033-900, Brazil., Riley LW; Division of Infectious Diseases and Vaccinology, University of California, Berkeley, CA 94720, USA., Cardoso CAA; Faculdade de Medicina, Universidade Federal Fluminense Rua Marquês de Paraná, 303, Centro, Niterói, RJ 24.033-900, Brazil.
Jazyk:	angličtina
Zdroj:	Journal of tropical pediatrics [J Trop Pediatr] 2023 Sep 07; Vol. 69 (5).
DOI:	10.1093/tropej/fmad030
Abstrakt:	Introduction: Congenital Zika syndrome (CZS) is a recently described disease. Our main objective was to evaluate and monitor, over 3 years, the ophthalmoscopic findings in children exposed to zika virus (ZIKV) during gestation. Methods: This prospective observational study was conducted in Rio de Janeiro, Brazil, between April 2016 and May 2019. We evaluated two groups with exanthema serving as a proxy for viremia: (i) children whose mothers had exanthema during pregnancy and (ii) children who had microcephaly without maternal exanthema during pregnancy. We performed indirect ophthalmoscopy at recruitment and every 6 months thereafter. We also tested the association between ocular findings with maternal exanthema, microcephaly, CZS and maternal infection confirmed by reverse transcriptase quantitative polymerase chain reaction and gender. Results: Of the 72 children included, 16 (22.2%) had optic nerve and/or retinal lesions. All 16 had CZS and 15 (93.7%) had microcephaly (14 at birth and 1 postnatally). The child with postnatally acquired microcephaly was born to a mother without exanthema during pregnancy. Fifty-six (77.8%) of the 72 children were followed for a median time of 24 months and none exhibited differences between admission and follow-up examinations. After logistic regression, only microcephaly at birth was associated with eye abnormalities (odds ratio, 77.015; 95% confidence interval, 8.85-670.38; p < 0.001). Conclusion: We observed that there was no progression of the lesions over the follow-up period. We also showed that the eye findings were associated only with microcephaly at birth. Attention should be paid to all children born during a ZIKV epidemic, regardless of maternal exanthema and/or microcephaly at birth. (© The Author(s) [2023]. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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