The impact of anti-malarial markets on artemisinin resistance: perspectives from Burkina Faso.

Autor: Guissou RM; Institut de Recherche en Sciences de la Sante, Centre National de la Recherche Scientifique et Technologique, Ouagadougou, Burkina Faso. rosyguiss@yahoo.fr., Amaratunga C; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Center for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., de Haan F; Copernicus Institute of Sustainable Development, Utrecht University, Utrecht, The Netherlands., Tou F; Institut des Sciences et Techniques, Bobo-Dioulasso, Burkina Faso., Cheah PY; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Center for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Yerbanga RS; Institut de Recherche en Sciences de la Sante, Centre National de la Recherche Scientifique et Technologique, Ouagadougou, Burkina Faso.; Institut des Sciences et Techniques, Bobo-Dioulasso, Burkina Faso., Moors EHM; Copernicus Institute of Sustainable Development, Utrecht University, Utrecht, The Netherlands., Dhorda M; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Center for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Tindana P; School of Public Health, College of Health Sciences, University of Ghana, Accra, Ghana., Boon WPC; Copernicus Institute of Sustainable Development, Utrecht University, Utrecht, The Netherlands., Dondorp AM; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Center for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Ouédraogo JB; Institut des Sciences et Techniques, Bobo-Dioulasso, Burkina Faso.
Jazyk: angličtina
Zdroj: Malaria journal [Malar J] 2023 Sep 13; Vol. 22 (1), pp. 269. Date of Electronic Publication: 2023 Sep 13.
DOI: 10.1186/s12936-023-04705-0
Abstrakt: Background: Widespread artemisinin resistance in Africa could be catastrophic when drawing parallels with the failure of chloroquine in the 1970s and 1980s. This article explores the role of anti-malarial market characteristics in the emergence and spread of arteminisin resistance in African countries, drawing on perspectives from Burkina Faso.
Methods: Data were collected through in-depth interviews and focus group discussions. A representative sample of national policy makers, regulators, public and private sector wholesalers, retailers, clinicians, nurses, and community members were purposively sampled. Additional information was also sought via review of policy publications and grey literature on anti-malarial policies and deployment practices in Burkina Faso.
Results: Thirty seven in-depth interviews and 6 focus group discussions were conducted. The study reveals that the current operational mode of anti-malarial drug markets in Burkina Faso promotes arteminisin resistance emergence and spread. The factors are mainly related to the artemisinin-based combination therapy (ACT) supply chain, to ACT quality, ACT prescription monitoring and to ACT access and misuse by patients.
Conclusion: Study findings highlight the urgent requirement to reform current characteristics of the anti-malarial drug market in order to delay the emergence and spread of artemisinin resistance in Burkina Faso. Four recommendations for public policy emerged during data analysis: (1) Address the suboptimal prescription of anti-malarial drugs, (2) Apply laws that prohibit the sale of anti-malarials without prescription, (3) Restrict the availability of street drugs, (4) Sensitize the population on the value of compliance regarding correct acquisition and intake of anti-malarials. Funding systems for anti-malarial drugs in terms of availability and accessibility must also be stabilized.
(© 2023. BioMed Central Ltd., part of Springer Nature.)
Databáze: MEDLINE
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