Reactive oxygen species creation by laser-irradiated indocyanine green as photodynamic therapy modality: an in vitro study.

Autor: Atta D; Spectroscopy Department, Physics Research Institute, National Research Centre, 33 El Behooth St., Dokki, Giza, 60014618, Egypt. De.kamal@nrc.sci.eg.; Nonlinear Optical Properties and Fluorescence Spectroscopy Unit, Physics Research Institute, National Research Centre, 33 El Behooth St., Dokki, Giza, 60014618, Egypt. De.kamal@nrc.sci.eg., Elarif A; Department of Oral Medicine, Faculty of Dentistry, Future University, Fifth Settlement, New Cairo, Egypt., Al Bahrawy M; Oral Medicine & Periodontology Department, Faculty of Dentistry, Ain Shams University, Abbassia, Cairo, Egypt.
Jazyk: angličtina
Zdroj: Lasers in medical science [Lasers Med Sci] 2023 Sep 14; Vol. 38 (1), pp. 213. Date of Electronic Publication: 2023 Sep 14.
DOI: 10.1007/s10103-023-03876-1
Abstrakt: Applications of lasers in phototherapy have been the trend for the last few decades. The photodynamic therapy process normally depends on photosensitizers and laser beams. Through this study, indocyanine green has been used as a photosensitizer, which is normally activated using laser lines between 750 and 805 nm. The activity of the indocyanine green to do fluorescence by other pulsed laser sources has been tested by fluorescence technique, and it has been proven that the laser lines at 810, 940, and 980nm are able to excite the indocyanine green with different extents. The indocyanine green activation has been tested by several laser lines (810, 940, and 980 nm) commonly used as surgical lasers. The generated oxygen has been measured after irradiating the indocyanine green with the different laser lines. A comparison has been made between laser irradiation as a pinpoint and a broad beam. It is found that the wide beam is more effective in activating oxygen production. In the end, it is concluded that lines 810 and 940nm were effective in activating the used dye, while the 980nm activity did not show enough efficiency.
(© 2023. The Author(s).)
Databáze: MEDLINE
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