Distinct patterns of biomarker expression for atypical intraductal proliferations in prostate cancer.

Autor: Martini C; Clinical and Health Sciences, University of South Australia, Adelaide, Australia. carmela.martino@unisa.edu.au., Logan JM; Clinical and Health Sciences, University of South Australia, Adelaide, Australia., Sorvina A; Clinical and Health Sciences, University of South Australia, Adelaide, Australia., Prabhakaran S; Department of Anatomical Pathology, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia., Ung BSY; Clinical and Health Sciences, University of South Australia, Adelaide, Australia., Johnson IRD; Clinical and Health Sciences, University of South Australia, Adelaide, Australia., Hickey SM; Clinical and Health Sciences, University of South Australia, Adelaide, Australia., Brooks RD; Clinical and Health Sciences, University of South Australia, Adelaide, Australia., Caruso MC; Clinical and Health Sciences, University of South Australia, Adelaide, Australia., Klebe S; Department of Anatomical Pathology, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.; Department of Surgical Pathology, SA Pathology at Flinders Medical Centre, Adelaide, Australia., Karageorgos L; Clinical and Health Sciences, University of South Australia, Adelaide, Australia., O'Leary JJ; Department of Histopathology, Trinity College Dublin, Dublin, Ireland., Delahunt B; Malaghan Institute for Medical Research, Wellington, New Zealand., Samaratunga H; Aquesta Uropathology and the University of Queensland, Brisbane, Qld, Australia., Brooks DA; Clinical and Health Sciences, University of South Australia, Adelaide, Australia.; Department of Histopathology, Trinity College Dublin, Dublin, Ireland.
Jazyk: angličtina
Zdroj: Virchows Archiv : an international journal of pathology [Virchows Arch] 2024 Oct; Vol. 485 (4), pp. 723-728. Date of Electronic Publication: 2023 Sep 14.
DOI: 10.1007/s00428-023-03643-1
Abstrakt: High-grade prostatic intraepithelial neoplasia (HGPIN) is a well-characterised precursor lesion in prostate cancer. The term atypical intraductal proliferations (AIP) describes lesions with features that are far too atypical to be considered HGPIN, yet insufficient to be diagnosed as intraductal carcinoma of the prostate (IDCP). Here, a panel of biomarkers was assessed to provide insights into the biological relationship between IDCP, HGPIN, and AIP and their relevance to current clinicopathological recommendations. Tissue samples from 86 patients with prostate cancer were assessed by routine haematoxylin and eosin staining and immunohistochemistry (IHC) with a biomarker panel (Appl1/Sortilin/Syndecan-1) and a PIN4 cocktail (34βE12+P63/P504S). Appl1 strongly labelled atypical secretory cells, effectively visualising intraductal lesions. Sortilin labelling was moderate-to-strong in > 70% of cases, while Syndecan-1 was moderate-to-strong in micropapillary HGPIN/AIP lesions (83% cases) versus flat/tufting HGPIN (≤ 20% cases). Distinct biomarker labelling patterns for atypical intraductal lesions of the prostate were observed, including early atypical changes (flat/tufting HGPIN) and more advanced atypical changes (micropapillary HGPIN/AIP). Furthermore, the biomarker panel may be used as a tool to overcome the diagnostic uncertainty surrounding AIP by supporting a definitive diagnosis of IDCP for such lesions displaying the same biomarker pattern as cribriform IDCP.
(© 2023. The Author(s).)
Databáze: MEDLINE
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