New perspectives on the causes and consequences of male meiotic drive.

Autor: Courret C; Department of Biology, University of Rochester, Rochester, NY 14627, USA. Electronic address: https://twitter.com/@CecileCourret., Wei X; Department of Biology, University of Rochester, Rochester, NY 14627, USA. Electronic address: https://twitter.com/@xiaolu_wei., Larracuente AM; Department of Biology, University of Rochester, Rochester, NY 14627, USA. Electronic address: alarracu@bio.Rochester.edu.
Jazyk: angličtina
Zdroj: Current opinion in genetics & development [Curr Opin Genet Dev] 2023 Dec; Vol. 83, pp. 102111. Date of Electronic Publication: 2023 Sep 11.
DOI: 10.1016/j.gde.2023.102111
Abstrakt: Gametogenesis is vulnerable to selfish genetic elements that bias their transmission to the next generation by cheating meiosis. These so-called meiotic drivers are widespread in plants, animals, and fungi and can impact genome evolution. Here, we summarize recent progress on the causes and consequences of meiotic drive in males, where selfish elements attack vulnerabilities in spermatogenesis. Advances in genomics provide new insights into the organization and dynamics of driving chromosomes in natural populations. Common themes, including small RNAs, gene duplications, and heterochromatin, emerged from these studies. Interdisciplinary approaches combining evolutionary genomics with molecular and cell biology are beginning to unravel the mysteries of drive and suppression mechanisms. These approaches also provide insights into fundamental processes in spermatogenesis and chromatin regulation.
Competing Interests: Declaration of Competing Interest We have no conflicts of interest to declare.
(Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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