Effect of Microsurgical Varicocele Repair on Sperm Capacitation and Probability of Generating a Pregnancy as Measured by Pre and Postoperative Novel Testing With Cap-Score.

Autor: Qalawena M; Department of Urology, University of Minnesota, Minneapolis MN; Department of Urology, Suez Canal University, Ismailia, Egypt. Electronic address: Qalaw001@umn.edu., Seaman E; New Jersey Urology, a Division of Summit Health, Millburn NJ., Johnson J; Department of Urology, University of Minnesota, Minneapolis MN., Nakib N; Department of Urology, University of Minnesota, Minneapolis MN., El-Sakka AI; Department of Urology, Suez Canal University, Ismailia, Egypt., Motawaa MA; Department of Urology, Suez Canal University, Ismailia, Egypt., Shaaban SM; Department of Urology, Suez Canal University, Ismailia, Egypt., Bodie JA; Department of Urology, University of Minnesota, Minneapolis MN.
Jazyk: angličtina
Zdroj: Urology [Urology] 2023 Nov; Vol. 181, pp. 63-68. Date of Electronic Publication: 2023 Sep 11.
DOI: 10.1016/j.urology.2023.08.033
Abstrakt: Objective: To study whether varicocele repair would improve sperm capacitation and probability of generating a pregnancy.
Methods: Data were collected prospectively from 40 consecutive adult men who presented with infertility confirmed by semen analysis (SA) and found to have a varicocele on exam or ultrasound who underwent unilateral or bilateral subinguinal microscopic varicocelectomy. We recorded pre and postoperative SA, Cap-Score, and probability of generating a pregnancy (PGP) with a 3-month follow-up. Values were compared using paired t test and Wilcox rank-sum test.
Results: Results showed a 17.4% relative increase in Cap-Score (23%-27% capacitation), 25% relative increase in PGP (24%-30%), as well as statistically significant improvements in sperm concentration, motility, and total sperm count postoperatively.
Conclusion: This study confirms that microsurgical varicocelectomy significantly improves sperm capacitation ability and improves the expected probability of generating a pregnancy within 3 rounds of intrauterine insemination. The improvement in sperm capacitation ability may help explain how varicocele repair may improve the chance of pregnancy, regardless of standard semen parameter improvements.
Competing Interests: Declaration of Competing Interest All authors have no conflict.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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