Endocannabinoid release at ventral hippocampal-amygdala synapses regulates stress-induced behavioral adaptation.

Autor:	Kondev V; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37232, USA., Najeed M; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37232, USA., Yasmin F; Northwestern Center for Psychiatric Neuroscience, Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Morgan A; Northwestern Center for Psychiatric Neuroscience, Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Loomba N; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37232, USA., Johnson K; Northwestern Center for Psychiatric Neuroscience, Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Adank DN; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37232, USA., Dong A; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China; PKU-IDG/McGoverrn Institute for Brain Research, Beijing, China; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China., Delpire E; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Li Y; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China; PKU-IDG/McGoverrn Institute for Brain Research, Beijing, China; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China; Chinese Institute for Brain Research, Beijing, China., Winder D; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA., Grueter BA; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Patel S; Northwestern Center for Psychiatric Neuroscience, Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: sachin.patel@northwestern.edu.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2023 Sep 26; Vol. 42 (9), pp. 113027. Date of Electronic Publication: 2023 Sep 12.
DOI:	10.1016/j.celrep.2023.113027
Abstrakt:	The endocannabinoid (eCB) system is a key modulator of glutamate release within limbic neurocircuitry and thus heavily modulates stress responsivity and adaptation. The ventral hippocampus (vHPC)-basolateral amygdala (BLA) circuit has been implicated in the expression of negative affective states following stress exposure and is modulated by retrograde eCB signaling. However, the mechanisms governing eCB release and the causal relationship between vHPC-BLA eCB signaling and stress-induced behavioral adaptations are not known. Here, we utilized in vivo optogenetic- and biosensor-based approaches to determine the temporal dynamics of activity-dependent and stress-induced eCB release at vHPC-BLA synapses. Furthermore, we demonstrate that genetic deletion of cannabinoid type-1 receptors selectively at vHPC-BLA synapses decreases active stress coping and exacerbates stress-induced avoidance and anhedonia phenotypes. These data establish the in vivo determinants of eCB release at limbic synapses and demonstrate that eCB signaling within vHPC-BLA circuitry serves to counteract adverse behavioral consequences of stress. Competing Interests: Declaration of interests S.P. is a scientific consultant for Psy Therapeutics, Janssen Pharmaceuticals, and Jazz Pharmaceuticals, unrelated to the present work. (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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