The performance of interferon gamma release assays in patients with nontuberculous mycobacterial infection: a systematic review and meta-analysis.

Autor: Guan CP; Department of Lab Medicine, Shandong Public Health Clinical Center, Shandong University, Jinan, 250013, China., Wu YH; Department of Lab Medicine, Shandong Public Health Clinical Center, Shandong University, Jinan, 250013, China., Wang XF; Department of Lab Medicine, Shandong Public Health Clinical Center, Shandong University, Jinan, 250013, China., He Y; Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, 530012, China., Zhang YA; Department of Cardiovascular Surgery, Shandong Public Health Clinical Center, Shandong University, Jinan, 250013, China.; Shandong Key Laboratory of Infectious Respiratory Disease, Jinan, 250013, China., Wang MS; Department of Lab Medicine, Shandong Public Health Clinical Center, Shandong University, Jinan, 250013, China. wangmaoshui@gmail.com.; Shandong Key Laboratory of Infectious Respiratory Disease, Jinan, 250013, China. wangmaoshui@gmail.com.
Jazyk: angličtina
Zdroj: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2023 Oct; Vol. 42 (10), pp. 1251-1262. Date of Electronic Publication: 2023 Sep 13.
DOI: 10.1007/s10096-023-04662-1
Abstrakt: Background: The actual positive rate of interferon gamma release assays (IGRAs) in patients with nontuberculous mycobacteria (NTM) infections remains unclear. This review and meta-analysis present the prevalence of positive IGRAs (T-SPOT.TB and QuantiFERON [QFT] tests) among patients infected with NTM isolates (with or without ESAT-6/CFP-10).
Methods: Several databases, including PubMed, Scopus, Embase, and Web of Science were searched (until June 18th, 2022). Studies that had the following data were included: (1) results of T-SPOT.TB, QuantiFERON (QFT) test, or both, (2) NTM species, and (3) NTM diseases, or NTM colonization. The metaprop command that incorporates a Freeman-Tukey double arcsine transformation is used for pooling proportions.
Results: A total of 11 articles (n = 929) were deemed eligible for inclusion. Meta-analysis identified that the overall pooled positive and indeterminate rates of IGRA results in patients with NTM infections was 16% and 5%, respectively. Subgroup analysis showed that the positive rate of IGRAs in patients infected with NTM (without ESAT-6/CFP-10) was 7% (95% CI, 1%-18%), and 44% (95%CI, 22%-68%) in patients infected with NTM (with ESAT-6/CFP-10). In addition, the indeterminate rate of QFT (7%, 95% CI: 4%-12%) was higher than that of T-SPOT.TB (0%; 95% CI, 0%-2%) among the overall population with NTM infections.
Conclusions: The IGRAs have a moderate positive rate for the diagnosis of NTM (expressing ESAT-6/CFP-10) infections, and a significant indeterminate rate is observed among the overall population infected with NTM. However, these findings should be interpreted with caution because of the high heterogeneity among studies.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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