Epstein-Barr virus LMP1 enhances levels of large extracellular vesicle-associated PD-L1.
| Autor: | Abou Harb M; Department of Biomedical Sciences, Florida State University College of Medicine , Tallahassee, Florida, USA., Meckes DG Jr; Department of Biomedical Sciences, Florida State University College of Medicine , Tallahassee, Florida, USA., Sun L; Department of Biomedical Sciences, Florida State University College of Medicine , Tallahassee, Florida, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of virology [J Virol] 2023 Oct 31; Vol. 97 (10), pp. e0021923. Date of Electronic Publication: 2023 Sep 13. |
| DOI: | 10.1128/jvi.00219-23 |
| Abstrakt: | Importance: A growing body of evidence has supported the notion that viruses utilize EVs and associated pathways to incorporate viral products. This allows for the evasion of an immune response while enabling viral spread within the host. Given that viral proteins often elicit strong antigenic peptides that are recognized by T cells, the regulation of the PD-L1 pathway through the overexpression of lEV-associated PD-L1 may serve as a strategy for immune evasion by viruses. The discovery that EBV LMP1 increases the secretion of PD-L1 in larger EVs identifies a new potential target for immune blockade therapy in EBV-associated cancers. Our findings may help to clarify the mechanism of LMP1-mediated enhancement of PD-L1 packaging into lEVs and may lead to the identification of more specific targets for treatment. Additionally, the identification of lEV biomarkers that predict a viral origin of disease could allow for more targeted therapies to be developed. Competing Interests: The authors declare no conflict of interest. |
| Databáze: | MEDLINE |
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