Effects of Skeleton Structure of Mesoporous Silica Nanoadjuvants on Cancer Immunotherapy.

Autor:	Tan J; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China., Ding B; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China., Chen H; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China., Meng Q; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China., Li J; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China., Yang C; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China., Zhang W; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China., Li X; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China., Han D; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China., Zheng P; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.; Key Laboratory of Superlight Materials & Surface Technology of Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin, 150001, China., Ma P; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China., Lin J; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China.
Jazyk:	angličtina
Zdroj:	Small (Weinheim an der Bergstrasse, Germany) [Small] 2024 Jan; Vol. 20 (3), pp. e2305567. Date of Electronic Publication: 2023 Sep 13.
DOI:	10.1002/smll.202305567
Abstrakt:	Mesoporous silica nanoparticles (MSNs) have been widely praised as nanoadjuvants in vaccine/tumor immunotherapy thanks to their excellent biocompatibility, easy-to-modify surface, adjustable particle size, and remarkable immuno-enhancing activity. However, the application of MSNs is still greatly limited by some severe challenges including the unclear and complicated relationships of structure and immune effect. Herein, three commonly used MSNs with different skeletons including MSN with tetrasulfide bonds (TMSN), MSN containing ethoxy framework (EMSN), and pure -Si-O-Si- framework of MSN (MSN) are comprehensively compared to study the impact of chemical construction on immune effect. The results fully demonstrate that the three MSNs have great promise in improving cellular immunity for tumor immunotherapy. Moreover, the TMSN performs better than the other two MSNs in antigen loading, cellular uptake, reactive oxygen species (ROS) generation, lymph node targeting, immune activation, and therapeutic efficiency. The findings provide a new paradigm for revealing the structure-function relationship of mesoporous silica nanoadjuvants, paving the way for their future clinical application. (© 2023 Wiley-VCH GmbH.)
Databáze:	MEDLINE
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