Extending arterial stiffness assessment along the circumference using beam-steered ARFI and wave-tracking: A proof-of-principle study in phantoms and ex vivo .

Autor:	Pruijssen JT; Medical Ultrasound Imaging Center (MUSIC), Department of Medical Imaging/Radiology, Radboud University Medical Center, Nijmegen, the Netherlands., Fekkes S; Medical Ultrasound Imaging Center (MUSIC), Department of Medical Imaging/Radiology, Radboud University Medical Center, Nijmegen, the Netherlands., Menssen J; Medical Ultrasound Imaging Center (MUSIC), Department of Medical Imaging/Radiology, Radboud University Medical Center, Nijmegen, the Netherlands., de Korte CL; Medical Ultrasound Imaging Center (MUSIC), Department of Medical Imaging/Radiology, Radboud University Medical Center, Nijmegen, the Netherlands.; Physics of Fluid Group, MESA+ Institute for Nanotechnology, and MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, the Netherlands., Hansen HHG; Medical Ultrasound Imaging Center (MUSIC), Department of Medical Imaging/Radiology, Radboud University Medical Center, Nijmegen, the Netherlands.
Jazyk:	angličtina
Zdroj:	Computational and structural biotechnology journal [Comput Struct Biotechnol J] 2023 Aug 26; Vol. 21, pp. 4288-4300. Date of Electronic Publication: 2023 Aug 26 (Print Publication: 2023).
DOI:	10.1016/j.csbj.2023.08.024
Abstrakt:	Background: To fully quantify arterial wall and plaque stiffness, acoustic radiation force impulse (ARFI)-induced wave-tracking along the entire vessel circumference is desired. However, attenuation and guided wave behavior in thin vessel walls limits wave-tracking to short trajectories. This study investigated the potential of beam-steered ARFI and wave-tracking to extend group velocity estimation over a larger proportion of the circumference compared to conventional 0° ARFI-induced wave-tracking. Methods: Seven vessel-mimicking polyvinyl alcohol cryogel phantoms with various dimensions and compositions and an ex vivo human carotid artery were imaged in a dedicated setup. For every 20⁰ phantom rotation, transverse group wave velocity measurements were performed with an Aixplorer Ultimate system and SL18-5 transducer using 0⁰/20⁰/-20⁰-angled ultrasound pushes. Transmural angular wave velocities were derived along 60⁰-trajectories. A 360⁰-angular velocity map was composed from the top-wall 60⁰-trajectories 0°-data, averaged over all physical phantom rotations (reference). For each phantom rotation, 360⁰-angular velocity maps were composed using 0°-data (0⁰-approach) or data from all angles (beam-steered approach). Percentages of rotations with visible waves and relative angular velocity errors compared to the reference map as function of the circumferential angle were determined for both approaches. Results: Reference 360°-angular velocity maps could be derived for all samples, representing their stiffness. Beam-steering decreased the proportion of the circumference where waves were untraceable by 20% in phantoms and 10% ex vivo , mainly at 0° push locations. Relative errors were similar for both approaches (phantoms: 10-15%, ex vivo : 15-35%). Conclusion: Beam-steering enables wave-tracking along a higher proportion of the wall circumference than 0⁰ ARFI-induced wave-tracking. Competing Interests: None. (© 2023 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu