Comparison of metrics to assess antibiotic use in small ruminants at a university referral clinic between 2005 and 2019.

Autor: Firth CL; Unit of Veterinary Public Health & Epidemiology, University of Veterinary Medicine, Vienna, Austria., Keppelmüller H; Unit of Veterinary Public Health & Epidemiology, University of Veterinary Medicine, Vienna, Austria., Käsbohrer A; Unit of Veterinary Public Health & Epidemiology, University of Veterinary Medicine, Vienna, Austria., Hund A; University Clinic for Ruminants, University of Veterinary Medicine, Vienna, Austria.; Agricultural Centre for Cattle, Grassland, Dairy, Game and Fisheries of Baden-Wuerttemberg (LAZBW), Aulendorf, Germany., Wittek T; University Clinic for Ruminants, University of Veterinary Medicine, Vienna, Austria.
Jazyk: angličtina
Zdroj: The Veterinary record [Vet Rec] 2024 Jan 06; Vol. 194 (1), pp. e3413. Date of Electronic Publication: 2023 Sep 12.
DOI: 10.1002/vetr.3413
Abstrakt: Background: Monitoring antibiotic use is essential to provide a framework enabling veterinarians to use antibiotics prudently.
Methods: Electronic medical records from the University of Veterinary Medicine's Clinic for Ruminants in Vienna were analysed with respect to sheep and goat antibiotic doses administered over a 15-year period (2005-2019). Antibiotic use was assessed using total milligrams per kilogram (mg/kg), total milligrams, number of doses administered, defined daily doses (DDD) for cattle and estimated DDD for sheep.
Results: A total of 5113 antibiotic doses were recorded over the 15-year period. Urinary tract disorders required the highest number of doses administered per animal (mean 16.9; median 16.0). Antibiotic use patterns varied according to the metrics used for analysis. By mg/kg, the largest proportion of antibiotics administered were penicillin/streptomycin (43.0% of the total mg/kg), followed by tetracyclines (17.3%) and sulphonamide/trimethoprim combinations (15.2%). By number of doses administered, the most frequently used antibiotics were penicillins (excluding combinations with streptomycin) (33.9% of total number of doses administered), fluoroquinolones (25.1%), third/fourth-generation cephalosporins (13.6%) and penicillin/streptomycin (13.4%).
Limitations: As the university clinic was a city-based referral centre, this analysis cannot be compared directly with antibiotic use in commercial herds or flocks.
Conclusions: The considered choice of antibiotic use metrics is essential for an effective and meaningful analysis of the responsible use of antibiotics by veterinarians in practice.
(© 2023 The Authors. Veterinary Record published by John Wiley & Sons Ltd on behalf of British Veterinary Association.)
Databáze: MEDLINE
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