| Autor: |
Bhattacharya T; Department of Food and Nutrition, College of Human Ecology, Kyung Hee University, 26 Kyunghee-daero, Dongdaemun-gu, Seoul 02447, Republic of Korea.; Nondestructive Bio-Sensing Laboratory, Dept. of Biosystems Machinery Engineering, College of Agriculture and Life Science, Chungnam National University, Daejeon 34134, Republic of Korea., Preetam S; Centre for Biotechnology, Siksha O Anusandhan (Deemed to be University), Bhubaneswar 751024, Odisha, India.; Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu 42988, Republic of Korea., Ghosh B; KIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar 751024, Odisha, India., Chakrabarti T; Department of Chemistry, Sir Padampat Singhania University, Bhatewar, Udaipur 313601, Rajasthan, India., Chakrabarti P; ITM SLS Baroda University, Vadodara 391510, Gujarat, India., Samal SK; Section of Immunology and Chronic Disease, Institute of Environmental Medicine, Karolinska Institutet, Stockholm 171 77, Sweden., Thorat N; Nuffield Department of Women's & Reproductive Health, Medical Science Division, John Radcliffe Hospital University of Oxford, Oxford OX3 9DU, United Kingdom.; Department of Physics, Bernal Institute and Limerick Digital Cancer Research Centre (LDCRC), University of Limerick, Castletroy, Limerick V94T9PX, Ireland. |
| Abstrakt: |
Applications of nanotechnology have increased the importance of research and nanocarriers, which have revolutionized the method of drug delivery to treat several diseases, including cancer, in the past few years. Cancer, one of the world's fatal diseases, has drawn scientists' attention for its multidrug resistance to various chemotherapeutic drugs. To minimize the side effects of chemotherapeutic agents on healthy cells and to develop technological advancement in drug delivery systems, scientists have developed an alternative approach to delivering chemotherapeutic drugs at the targeted site by integrating it inside the nanocarriers like synthetic polymers, nanotubes, micelles, dendrimers, magnetic nanoparticles, quantum dots (QDs), lipid nanoparticles, nano-biopolymeric substances, etc., which has shown promising results in both preclinical and clinical trials of cancer management. Besides that, nanocarriers, especially biopolymeric nanoparticles, have received much attention from researchers due to their cost-effectiveness, biodegradability, treatment efficacy, and ability to target drug delivery by crossing the blood-brain barrier. This review emphasizes the fabrication processes, the therapeutic and theragnostic applications, and the importance of different biopolymeric nanocarriers in targeting cancer both in vitro and in vivo , which conclude with the challenges and opportunities of future exploration using biopolymeric nanocarriers in onco-therapy with improved availability and reduced toxicity. |
