Factors associated with the initiation of laxative use in the same patients with schizophrenia over a 20-year period: Retrospective cohort study.

Autor: Kawamata Y; Department of Psychiatry, School of Medicine, Dokkyo Medical University, Tochigi, Japan.; Department of Psychiatry, Kikuchi Hospital, Tochigi, Japan., Sugawara N; Department of Psychiatry, School of Medicine, Dokkyo Medical University, Tochigi, Japan.; Department of Psychiatry, TMC Shimotsuga, Tochigi, Japan., Sasaki T; Department of Psychiatry, School of Medicine, Dokkyo Medical University, Tochigi, Japan.; Department of Psychiatry, Asahi Hospital, Tochigi, Japan., Yokoyama S; Department of Psychiatry, School of Medicine, Dokkyo Medical University, Tochigi, Japan.; Department of Psychiatry, Aoki Hospital, Tochigi, Japan., Okayasu H; Department of Psychiatry, School of Medicine, Dokkyo Medical University, Tochigi, Japan.; Department of Psychiatry, Fudogaoka Hospital, Saitama, Japan., Shinozaki M; Department of Psychiatry, School of Medicine, Dokkyo Medical University, Tochigi, Japan.; Department of Psychiatry, Takizawa Hospital, Tochigi, Japan., Takeuchi Y; Department of Psychiatry, School of Medicine, Dokkyo Medical University, Tochigi, Japan.; Department of Psychiatry, Okamotodai Hospital, Tochigi, Japan., Sato A; Department of Psychiatry, School of Medicine, Dokkyo Medical University, Tochigi, Japan.; Department of Psychiatry, Muroi Hospital, Tochigi, Japan., Ishikawa T; Department of Psychiatry, School of Medicine, Dokkyo Medical University, Tochigi, Japan.; Department of Psychiatry, Saitama-Konan Hospital, Saitama, Japan., Komahashi-Sasaki H; Department of Psychiatry, School of Medicine, Dokkyo Medical University, Tochigi, Japan.; Department of Psychiatry, Kanuma Hospital, Tochigi, Japan., Miyazaki K; Department of Neuropsychiatry, Hirosaki-Aiseikai Hospital, Aomori, Japan., Fukasawa T; Department of Psychiatry, Seinan Hospital, Aomori, Japan., Furukori H; Department of Neuropsychiatry, Kuroichi-Akebono Hospital, Aomori, Japan., Yasui-Furukori N; Department of Psychiatry, School of Medicine, Dokkyo Medical University, Tochigi, Japan.; Department of Psychiatry, TMC Shimotsuga, Tochigi, Japan.
Jazyk: angličtina
Zdroj: Neuropsychopharmacology reports [Neuropsychopharmacol Rep] 2024 Mar; Vol. 44 (1), pp. 60-66. Date of Electronic Publication: 2023 Sep 12.
DOI: 10.1002/npr2.12378
Abstrakt: Background: Constipation is a common adverse effect of antipsychotics, but little investigation has been conducted. We aimed to address the factors associated with the initiation of laxative use in the same patients with schizophrenia over a 20-year period.
Methods: We enrolled patients with schizophrenia attending each hospital (n = 14) from April 1, 2021, and retrospectively examined all prescriptions as of April 1, 2016, 2011, 2006, and 2001, every 5 years starting in 2021, for this population. 716 participants with complete data were included in the analysis. The Cochran Q test followed by Bonferroni correction and the Cochran-Armitage trend test were used to determine the differences and trends of the frequency of each laxative. Multivariate logistic regression analysis was performed to assess the factors on the initiation of laxative use over a 20-year period.
Results: Of the patients, 25.1% were treated with laxatives in 2001, and 34.1% were treated in 2021. The numbers of patients treated with any laxatives significantly differed over the 20-year period, with a significant increasing trend. In all laxatives, the numbers of patients treated with magnesium oxide, lubiprostone and elobixibat differed with a significant increasing trend. Female sex, age, the total DZP equivalent dose, and the doses of levomepromazine maleate, olanzapine, quetiapine, zotepine, lithium, and carbamazepine in 2021 were significant factors associated with the initiation of laxative use over the 20-year period.
Conclusions: Careful monitoring is needed for patients treated with levomepromazine maleate, olanzapine, quetiapine and zotepine. Optimizing prescriptions according to treatment guidelines could reduce antipsychotic-induced constipation.
(© 2023 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsychopharmacology.)
Databáze: MEDLINE
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