Comparison of the novel membrane-based carbon dioxide filter memsorb™ with a chemical granulate absorbent using a high-fidelity lung simulator: a prospective randomized in vitro trial.

Autor: Noppens RR; Department of Anesthesia & Perioperative Medicine, Schulich School of Medicine & Dentistry, LHSC, University Hospital, University of Western Ontario, 339 Windermere Road, London, ON, N6G 2V4, Canada. rnoppens@uwo.ca., Dar FI; Department of Anesthesia & Perioperative Medicine, Schulich School of Medicine & Dentistry, LHSC, University Hospital, University of Western Ontario, 339 Windermere Road, London, ON, N6G 2V4, Canada., Banik S; Department of Anesthesia & Perioperative Medicine, Schulich School of Medicine & Dentistry, LHSC, University Hospital, University of Western Ontario, 339 Windermere Road, London, ON, N6G 2V4, Canada.
Jazyk: angličtina
Zdroj: Canadian journal of anaesthesia = Journal canadien d'anesthesie [Can J Anaesth] 2023 Oct; Vol. 70 (10), pp. 1643-1647. Date of Electronic Publication: 2023 Sep 11.
DOI: 10.1007/s12630-023-02563-7
Abstrakt: Purpose: Memsorb™ is a novel device for carbon dioxide (CO 2 ) removal from anesthesia circuits via a semipermeable polymeric membrane. We evaluated the performance of the memsorb device for the removal of CO 2 in an Aisys™ CS 2 machine and compared it with a standard chemical granulate absorber (CGA) using a high-fidelity lung simulator.
Methods: We used an in vitro lung simulator (DUCt) to control CO 2 release by imitating alveolar gas exchange. The ventilator settings were identical for all measurements. The fresh gas flow (FGF) was randomized to either 0.5 L·min -1 or 2 L·min -1 , completing three trials for each FGF for either memsorb or CGA. The EtCO 2 and F I CO 2 levels were recorded for 30 min in each setting.
Results: EtCO 2 was comparable between the groups with 2 L·min -1 FGF over the observation period. F I CO 2 was significantly higher in the memsorb group during the trial (2 L·min -1 ; 3.9 mm Hg; 95% CI, 4.4 to 3.3; P < 0.001). EtCO 2 with 0.5 L·min -1 FGF was higher with memsorb than with CGA over the observation period (3.7 mm Hg; 95% CI, 2.7 to 4.7; P = 0.004). With 0.5 L·min -1 FGF, F I CO 2 was significantly higher in the memsorb group compared with CGA over the whole observation period (6 mm Hg; 95% CI, 6.4 to 5.5; P < 0.001).
Discussion: CO 2 was successfully removed from the anesthesia circuit. F I CO 2 was significantly higher with memsorb throughout the observation period. Nevertheless, the clinical impact of these observations remains unclear. Further clinical trials are required to determine the utility of the novel device.
(© 2023. Canadian Anesthesiologists' Society.)
Databáze: MEDLINE
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