Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal.

Autor: Borges V; Genomics and Bioinformatics Unit, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal., Duque MP; Epidemiology and Statistics Division, Directorate-General of Health, Lisbon, Portugal.; Pathogen Dynamics Group, Department of Genetics, University of Cambridge, Cambridge, United Kingdom., Martins JV; Epidemiology and Statistics Division, Directorate-General of Health, Lisbon, Portugal., Vasconcelos P; Public Health Emergency Centre, Directorate-General of Health, Lisbon, Portugal., Ferreira R; Genomics and Bioinformatics Unit, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal., Sobral D; Genomics and Bioinformatics Unit, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal., Pelerito A; Emergency Response and Biopreparedness Unit, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal., de Carvalho IL; Emergency Response and Biopreparedness Unit, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal., Núncio MS; Emergency Response and Biopreparedness Unit, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal., Borrego MJ; National Reference Laboratory for Sexually Transmitted Infections, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal., Roemer C; Biozentrum, University of Basel, Basel, Switzerland.; Swiss Institute of Bioinformatics, Basel, Switzerland., Neher RA; Biozentrum, University of Basel, Basel, Switzerland.; Swiss Institute of Bioinformatics, Basel, Switzerland., O'Driscoll M; Pathogen Dynamics Group, Department of Genetics, University of Cambridge, Cambridge, United Kingdom., Rocha R; National Reference Laboratory for Sexually Transmitted Infections, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal., Lopo S; National Reference Laboratory for Sexually Transmitted Infections, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal., Neves R; National Reference Laboratory for Sexually Transmitted Infections, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal., Palminha P; National Reference Laboratory for Sexually Transmitted Infections, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal., Coelho L; Genomics and Bioinformatics Unit, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal., Nunes A; Genomics and Bioinformatics Unit, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal.; Veterinary and Animal Research Centre (CECAV), Faculty of Veterinary Medicine, Lusófona University, Lisbon, Portugal., Isidro J; Genomics and Bioinformatics Unit, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal., Pinto M; Genomics and Bioinformatics Unit, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal., Santos JD; Genomics and Bioinformatics Unit, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal., Mixão V; Genomics and Bioinformatics Unit, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal., Santos D; Technology and Innovation Unit, Department of Human Genetics, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal., Duarte S; Technology and Innovation Unit, Department of Human Genetics, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal., Vieira L; Technology and Innovation Unit, Department of Human Genetics, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal., Martins F; Technical Board, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal., Machado J; Department Coordination, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal., Veríssimo VC; Epidemiology and Statistics Division, Directorate-General of Health, Lisbon, Portugal.; Public Health Unit, ACES Cascais, ARSLVT, Cascais, Portugal., Grau B; Epidemiology and Statistics Division, Directorate-General of Health, Lisbon, Portugal.; Public Health Emergency Centre, Directorate-General of Health, Lisbon, Portugal.; ECDC Fellowship Programme, Field Epidemiology path (EPIET), European Centre for Disease Prevention and Control (ECDC), Solna, Sweden.; Directorate of Information and Analysis, Directorate-General of Health, Lisbon, Portugal., Peralta-Santos A; Directorate of Information and Analysis, Directorate-General of Health, Lisbon, Portugal.; Comprehensive Health Research Centre (CHRC), Escola Nacional de Saúde Pública, Universidade NOVA de Lisboa, Lisbon, Portugal., Neves J; Serviço de Dermatovenereologia, Consulta de DST, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal., Caldeira M; Serviço de Dermatovenereologia, Consulta de DST, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal., Pestana M; Serviço de Dermatovenereologia, Consulta de DST, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal., Fernandes C; Serviço de Dermatovenereologia, Consulta de DST, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal., Caria J; Serviço de Doenças Infeciosas, Hospital de Curry Cabral, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal., Pinto R; Serviço de Doenças Infeciosas, Hospital de Curry Cabral, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal., Póvoas D; Serviço de Doenças Infeciosas, Hospital de Curry Cabral, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal.; Instituto Gulbenkian de Ciência, Oeiras, Portugal., Maltez F; Serviço de Doenças Infeciosas, Hospital de Curry Cabral, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal., Sá AI; Unidade de Doenças Sexualmente Transmissíveis da Lapa, Lisbon, Portugal., Salvador MB; Unidade de Doenças Sexualmente Transmissíveis da Lapa, Lisbon, Portugal., Teófilo E; GAT - Grupo de Ativistas em Tratamentos, Av. Paris, Lisbon, Portugal., Rocha M; GAT - Grupo de Ativistas em Tratamentos, Av. Paris, Lisbon, Portugal., Moneti V; GAT - Grupo de Ativistas em Tratamentos, Av. Paris, Lisbon, Portugal., Duque LM; GAT - Grupo de Ativistas em Tratamentos, Av. Paris, Lisbon, Portugal., E Silva FF; GAT - Grupo de Ativistas em Tratamentos, Intendente, Lisbon, Portugal., Baptista T; GAT - Grupo de Ativistas em Tratamentos, Intendente, Lisbon, Portugal., Vasconcelos J; Serviço de Doenças Infeciosas e Medicina Tropical, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal., Casanova S; Serviço de Doenças Infeciosas e Medicina Tropical, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal., Mansinho K; Serviço de Doenças Infeciosas e Medicina Tropical, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal., Alves JV; Serviço de Doenças Infeciosas e Medicina Tropical, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal., Alves J; Serviço de Dermatovenereologia, Hospital Garcia de Orta, Almada, Portugal., Silva A; Serviço de Dermatovenereologia, Hospital Garcia de Orta, Almada, Portugal., Alpalhão M; Dermatology Department, Centro Hospitalar Universitário Lisboa Norte EPE, Lisbon, Portugal.; Dermatology Research Unit (PFilipe Lab), Instituto de Medicina Molecular João Lobo Antunes, University of Lisbon, Lisbon, Portugal.; Dermatology University Clinic, Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Brazão C; Dermatology Department, Centro Hospitalar Universitário Lisboa Norte EPE, Lisbon, Portugal., Sousa D; Dermatology Department, Centro Hospitalar Universitário Lisboa Norte EPE, Lisbon, Portugal., Filipe P; Dermatology Department, Centro Hospitalar Universitário Lisboa Norte EPE, Lisbon, Portugal.; Dermatology Research Unit (PFilipe Lab), Instituto de Medicina Molecular João Lobo Antunes, University of Lisbon, Lisbon, Portugal.; Dermatology University Clinic, Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Pacheco P; Serviço de Infeciologia, Hospital Professor Doutor Fernando Fonseca, Amadora, Portugal., Peruzzu F; Serviço de Infeciologia, Hospital Professor Doutor Fernando Fonseca, Amadora, Portugal., de Jesus RP; Serviço de Infeciologia, Hospital Professor Doutor Fernando Fonseca, Amadora, Portugal., Ferreira L; Serviço Infeciologia do CHUP, Largo Professor Abel Salazar, Porto, Portugal., Mendez J; Serviço Infeciologia do CHUP, Largo Professor Abel Salazar, Porto, Portugal., Jordão S; Serviço de Doenças Infeciosas, Hospital Pedro Hispano - ULS Matosinhos, Matosinhos, Portugal., Duarte F; Serviço de Doenças Infeciosas, Hospital Pedro Hispano - ULS Matosinhos, Matosinhos, Portugal., Gonçalves MJ; Serviço de Doenças Infeciosas, Hospital Pedro Hispano - ULS Matosinhos, Matosinhos, Portugal., Pena E; Serviço de Doenças Infeciosas, Hospital Pedro Hispano - ULS Matosinhos, Matosinhos, Portugal., Silva CN; Serviço de Doenças Infeciosas, Centro Hospitalar Universitário de São João, Porto, Portugal., Guimarães AR; Serviço de Doenças Infeciosas, Centro Hospitalar Universitário de São João, Porto, Portugal., Tavares M; Serviço de Doenças Infeciosas, Centro Hospitalar Universitário de São João, Porto, Portugal., Freitas G; National Health Authority, Directorate-General of Health, Lisbon, Portugal., Cordeiro R; Emergency Response and Biopreparedness Unit, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal., Gomes JP; Genomics and Bioinformatics Unit, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal. j.paulo.gomes@insa.min-saude.pt.; Veterinary and Animal Research Centre (CECAV), Faculty of Veterinary Medicine, Lusófona University, Lisbon, Portugal. j.paulo.gomes@insa.min-saude.pt.
Jazyk: angličtina
Zdroj: Nature medicine [Nat Med] 2023 Oct; Vol. 29 (10), pp. 2509-2517. Date of Electronic Publication: 2023 Sep 11.
DOI: 10.1038/s41591-023-02542-x
Abstrakt: Pathogen genome sequencing during epidemics enhances our ability to identify and understand suspected clusters and investigate their relationships. Here, we combine genomic and epidemiological data of the 2022 mpox outbreak to better understand early viral spread, diversification and transmission dynamics. By sequencing 52% of the confirmed cases in Portugal, we identified the mpox virus sublineages with the highest impact on case numbers and fitted them into a global context, finding evidence that several international sublineages probably emerged or spread early in Portugal. We estimated a 62% infection reporting rate and that 1.3% of the population of men who have sex with men in Portugal were infected. We infer the critical role played by sexual networks and superspreader gatherings, such as sauna attendance, in the dissemination of mpox virus. Overall, our findings highlight genomic epidemiology as a tool for the real-time monitoring and control of mpox epidemics, and can guide future vaccine policy in a highly susceptible population.
(© 2023. The Author(s).)
Databáze: MEDLINE
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