ENHANCED EFFICACY OF RESVERATROL-LOADED SILVER NANOPARTICLE IN ATTENUATING SEPSIS-INDUCED ACUTE LIVER INJURY: MODULATION OF INFLAMMATION, OXIDATIVE STRESS, AND SIRT1 ACTIVATION.

Autor:	Üstündağ H; Department of Physiology, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan 2400, Türkiye., Danişman Kalindemirtaş F; Department of Physiology, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan 2400, Türkiye., Doğanay S; Department of Physiology, Faculty of Medicine, Sakarya University, Sakarya, Türkiye., Demir Ö; Department of Histology, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan 2400, Türkiye., Kurt N; Department of Biochemistry, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan, Türkiye., Tahir Huyut M; Department of Biostatistics and Medical Informatics, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan, Türkiye., Özgeriş B; Department of Nutrition and Dietetics, Faculty of Health Sciences, Ataturk University, Erzurum, Türkiye., Kariper İA; Education Faculty, Erciyes University, Department of Science Education, Kayseri, Türkiye.
Jazyk:	angličtina
Zdroj:	Shock (Augusta, Ga.) [Shock] 2023 Nov 01; Vol. 60 (5), pp. 688-697. Date of Electronic Publication: 2023 Sep 05.
DOI:	10.1097/SHK.0000000000002218
Abstrakt:	Abstract: Sepsis-induced acute liver injury is a life-threatening condition involving inflammation, oxidative stress, and endothelial dysfunction. In the present study, the preventive effects of resveratrol (RV) alone and RV-loaded silver nanoparticles (AgNPs + RV) against sepsis-induced damage were investigated and compared in a rat model of polymicrobial sepsis induced by cecal ligation and puncture (CLP). Rats were divided into four groups: Sham, CLP, RV, and AgNPs + RV. Pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation, presepsin, procalcitonin (PCT), 8-hydroxy-2'-deoxyguanosine (8-OHDG), vascular endothelial growth factor (VEGF), and sirtuin-1 (SIRT1) levels were assessed to determine the treatments' effects. AgNPs + RV treatment significantly reduced pro-inflammatory cytokines, NF-κB activation, presepsin, PCT, 8-OHDG, and VEGF levels compared with the CLP group, indicating attenuation of sepsis-induced liver injury. Both RV and AgNPs + RV treatments increased SIRT1 levels, suggesting a potential role of SIRT1 activation in mediating the protective effects. In conclusion, AgNPs + RV treatment demonstrated extremely enhanced efficacy in alleviating sepsis-induced liver injury by modulating inflammation, oxidative stress, and endothelial dysfunction, potentially mediated through SIRT1 activation. In this study, the effect of AgNPs + RV on sepsis was evaluated for the first time, and these findings highlight AgNPs + RV as a promising therapeutic strategy for managing sepsis-induced liver injury, warranting further investigation. Competing Interests: Conflict of interest statement: The authors declare that they have no conflicts of interest. (Copyright © 2023 by the Shock Society.)
Databáze:	MEDLINE
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