Nitro-oleic acid ameliorates erectile dysfunction in a streptozotocin-induced rat model of diabetes by inhibiting oxidative stress and apoptosis and activating the NO/cGMP pathway.

Autor:	Zhao CB; Department of Urology, Shandong Provincial Hospital, Shandong University, Jinan 250012, China.; Department of Andrology, Liaocheng People's Hospital, Shandong University, Liaocheng 252000, China., Chen WB; Department of Urology, Shandong Provincial Hospital, Shandong University, Jinan 250012, China., Wang WZ; Department of Urology, Shandong Provincial Hospital, Shandong University, Jinan 250012, China.; Department of Urology, The Second Hospital of Shandong University, Jinan 250012, China., Gong FX; Department of Urology, Shandong Provincial Hospital, Shandong University, Jinan 250012, China.; Department of Urology, The Second Hospital of Shandong University, Jinan 250012, China., Fan CQ; Department of Physiology, School of Basic Medical Sciences, Shandong University, Jinan 250012, China., Li Y; Department of Physiology, School of Basic Medical Sciences, Shandong University, Jinan 250012, China., Lan T; Department of Physiology, School of Basic Medical Sciences, Shandong University, Jinan 250012, China., Wang WJ; Department of Physiology, School of Basic Medical Sciences, Shandong University, Jinan 250012, China., Yuan MZ; Department of Urology, Shandong Provincial Hospital, Shandong University, Jinan 250012, China.
Jazyk:	angličtina
Zdroj:	Asian journal of andrology [Asian J Androl] 2024 Jan 01; Vol. 26 (1), pp. 57-66. Date of Electronic Publication: 2023 Aug 08.
DOI:	10.4103/aja202331
Abstrakt:	The major vascular complications associated with diabetes make the management of diabetic mellitus erectile dysfunction (DMED) a challenging endeavor. Notable factors contributing to DMED include oxidative stress, nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) pathway activation, and apoptosis, while nitro-oleic acid (NO 2 -OA) has been shown to be beneficial in treating these aspects of this condition. We, herein, investigated the effects and possible mechanisms of NO 2 -OA on erectile function as assessed in a streptozotocin-induced rat model of diabetes. Our results revealed that the erectile function of DMED rats was significantly impaired compared with that of the control group. However, in response to 4 weeks of NO 2 -OA treatment, there was an improvement in erectile function. The expression of oxidative stress-related indicators was significantly increased and the NO/cGMP pathway was impaired in the DMED group. The expression of proapoptotic factors was increased, while that of antiapoptotic factors was decreased in the DMED group. Moreover, the cell morphology in the cavernous tissue of the DMED group also changed adversely. NO 2 -OA treatment significantly reversed all these changes observed in the DMED group. In conclusion, NO 2 -OA treatment partially improved erectile function in DMED rats through mechanisms that included inhibition of oxidative stress, activation of the NO/cGMP pathway, and a reduction in apoptosis. (Copyright © 2023 Copyright: © The Author(s)(2023).)
Databáze:	MEDLINE
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